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10.3390/genes11060645

http://scihub22266oqcxt.onion/10.3390/genes11060645
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32545271!7349178!32545271
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suck abstract from ncbi


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pmid32545271      Genes+(Basel) 2020 ; 11 (6): ä
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  • Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract #MMPMID32545271
  • Lee JJ; Kopetz S; Vilar E; Shen JP; Chen K; Maitra A
  • Genes (Basel) 2020[Jun]; 11 (6): ä PMID32545271show ga
  • There is increasing evidence of gastrointestinal (GI) infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We surveyed the co-expression of SARS-CoV-2 entry genes ACE2 and TMPRSS2 throughout the GI tract to assess potential sites of infection. Publicly available and in-house single-cell RNA-sequencing datasets from the GI tract were queried. Enterocytes from the small intestine and colonocytes showed the highest proportions of cells co-expressing ACE2 and TMPRSS2. Therefore, the lower GI tract represents the most likely site of SARS-CoV-2 entry leading to GI infection.
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Base Sequence[MESH]
  • |Betacoronavirus/*metabolism[MESH]
  • |COVID-19[MESH]
  • |Cells, Cultured[MESH]
  • |Coronavirus Infections/pathology[MESH]
  • |Enterocytes/*metabolism/virology[MESH]
  • |Gastrointestinal Diseases/virology[MESH]
  • |Humans[MESH]
  • |Lower Gastrointestinal Tract/*metabolism/virology[MESH]
  • |Membrane Proteins/genetics/metabolism[MESH]
  • |Pandemics[MESH]
  • |Peptidyl-Dipeptidase A/*genetics/metabolism[MESH]
  • |Pneumonia, Viral/pathology[MESH]
  • |SARS-CoV-2[MESH]
  • |Sequence Analysis[MESH]
  • |Serine Endopeptidases/*genetics/metabolism[MESH]


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