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  • Potential of Flavonoid-Inspired Phytomedicines against COVID-19 #MMPMID32545268
  • Ngwa W; Kumar R; Thompson D; Lyerly W; Moore R; Reid TE; Lowe H; Toyang N
  • Molecules 2020[Jun]; 25 (11): ä PMID32545268show ga
  • Flavonoids are widely used as phytomedicines. Here, we report on flavonoid phytomedicines with potential for development into prophylactics or therapeutics against coronavirus disease 2019 (COVID-19). These flavonoid-based phytomedicines include: caflanone, Equivir, hesperetin, myricetin, and Linebacker. Our in silico studies show that these flavonoid-based molecules can bind with high affinity to the spike protein, helicase, and protease sites on the ACE2 receptor used by the severe acute respiratory syndrome coronavirus 2 to infect cells and cause COVID-19. Meanwhile, in vitro studies show potential of caflanone to inhibit virus entry factors including, ABL-2, cathepsin L, cytokines (IL-1beta, IL-6, IL-8, Mip-1alpha, TNF-alpha), and PI4Kiiibeta as well as AXL-2, which facilitates mother-to-fetus transmission of coronavirus. The potential for the use of smart drug delivery technologies like nanoparticle drones loaded with these phytomedicines to overcome bioavailability limitations and improve therapeutic efficacy are discussed.
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/chemistry/*pharmacology[MESH]
  • |Betacoronavirus/chemistry/*drug effects/growth & development[MESH]
  • |Binding Sites[MESH]
  • |COVID-19[MESH]
  • |Chloroquine/chemistry/pharmacology[MESH]
  • |Coronavirus Infections/*drug therapy/genetics[MESH]
  • |Coronavirus OC43, Human/chemistry/*drug effects/growth & development[MESH]
  • |Drug Carriers/administration & dosage/chemistry[MESH]
  • |Flavonoids/chemistry/*pharmacology[MESH]
  • |Humans[MESH]
  • |Interleukins/antagonists & inhibitors/chemistry/genetics/metabolism[MESH]
  • |Leukocytes, Mononuclear/drug effects/virology[MESH]
  • |Lung/drug effects/pathology/virology[MESH]
  • |Mice[MESH]
  • |Molecular Docking Simulation[MESH]
  • |Nanoparticles/administration & dosage/chemistry[MESH]
  • |Pandemics[MESH]
  • |Peptidyl-Dipeptidase A/*chemistry/genetics/metabolism[MESH]
  • |Phytotherapy/methods[MESH]
  • |Pneumonia, Viral/*drug therapy/genetics[MESH]
  • |Primary Cell Culture[MESH]
  • |Protein Binding[MESH]
  • |Protein Interaction Domains and Motifs[MESH]
  • |Protein-Tyrosine Kinases/antagonists & inhibitors/chemistry/genetics/metabolism[MESH]
  • |SARS-CoV-2[MESH]
  • |Spike Glycoprotein, Coronavirus/antagonists & inhibitors/*chemistry/genetics/metabolism[MESH]
  • |Thermodynamics[MESH]
  • |Virus Internalization/drug effects[MESH]

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  • suck abstract from ncbi

    ä 11.25 2020