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  • Strategies to Prevent SARS-CoV-2-Mediated Eosinophilic Disease in Association with COVID-19 Vaccination and Infection #MMPMID32544911
  • Simon HU; Karaulov AV; Bachmann MF
  • Int Arch Allergy Immunol 2020[]; 181 (8): 624-628 PMID32544911show ga
  • A vaccine to protect against COVID-19 is urgently needed. Such a vaccine should efficiently induce high-affinity neutralizing antibodies which neutralize SARS-CoV-2, the cause of COVID-19. However, there is a concern regarding both vaccine-induced eosinophilic lung disease and eosinophil-associated Th2 immunopotentiation following infection after vaccination. Here, we review the anticipated characteristics of a COVID-19 vaccine to avoid vaccine-associated eosinophil immunopathology.
  • |Antibodies, Neutralizing/biosynthesis[MESH]
  • |Betacoronavirus/*immunology[MESH]
  • |Coronavirus Infections/immunology/*prevention & control[MESH]
  • |Eosinophils/*physiology[MESH]
  • |Humans[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Pneumonia, Viral/*prevention & control[MESH]
  • |Th2 Cells/*immunology[MESH]
  • |Vaccination/*adverse effects[MESH]
  • |Viral Vaccines/*adverse effects/immunology[MESH]

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  • suck abstract from ncbi

    624 8.181 2020