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10.1016/j.chom.2020.05.014 http://scihub22266oqcxt.onion/10.1016/j.chom.2020.05.014 32544459!7295478!32544459     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Host+Microbe 2020 ; 28 (2): 322-334.e5 Nephropedia Template TP {{tp|p=32544459|t=2020. BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment |pdf=|usr=}}{{32544459}} gab.com Text BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=32544459 #FOAvip Induction of trained immunity by Bacille-Calmette-Guerin (BCG) vaccination mediates beneficial heterologous effects, but the mechanisms underlying its persistence and magnitude remain elusive. In this study, we show that BCG vaccination in healthy human volunteers induces a persistent transcriptional program connected to myeloid cell development and function within the hematopoietic stem and progenitor cell (HSPC) compartment in the bone marrow. We identify hepatic nuclear factor (HNF) family members 1a and b as crucial regulators of this transcriptional shift. These findings are corroborated by higher granulocyte numbers in BCG-vaccinated infants, HNF1 SNP variants that correlate with trained immunity, and elevated serum concentrations of the HNF1 target alpha-1 antitrypsin. Additionally, transcriptomic HSPC remodeling was epigenetically conveyed to peripheral CD14(+) monocytes, displaying an activated transcriptional signature three months after BCG vaccination. Taken together, transcriptomic, epigenomic, and functional reprogramming of HSPCs and peripheral monocytes is a hallmark of BCG-induced trained immunity in humans. Twit Text FOAVip BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=32544459 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32544459 #FOAvip English Wikipedia <ref>{{Cite pmid|32544459}}</ref> BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment #MMPMID32544459 Cirovic B; de Bree LCJ; Groh L; Blok BA; Chan J; van der Velden WJFM; Bremmers MEJ; van Crevel R; Handler K; Picelli S; Schulte-Schrepping J; Klee K; Oosting M; Koeken VACM; van Ingen J; Li Y; Benn CS; Schultze JL; Joosten LAB; Curtis N; Netea MG; Schlitzer A Cell Host Microbe 2020[Aug]; 28 (2): 322-334.e5 PMID32544459show ga Induction of trained immunity by Bacille-Calmette-Guerin (BCG) vaccination mediates beneficial heterologous effects, but the mechanisms underlying its persistence and magnitude remain elusive. In this study, we show that BCG vaccination in healthy human volunteers induces a persistent transcriptional program connected to myeloid cell development and function within the hematopoietic stem and progenitor cell (HSPC) compartment in the bone marrow. We identify hepatic nuclear factor (HNF) family members 1a and b as crucial regulators of this transcriptional shift. These findings are corroborated by higher granulocyte numbers in BCG-vaccinated infants, HNF1 SNP variants that correlate with trained immunity, and elevated serum concentrations of the HNF1 target alpha-1 antitrypsin. Additionally, transcriptomic HSPC remodeling was epigenetically conveyed to peripheral CD14(+) monocytes, displaying an activated transcriptional signature three months after BCG vaccination. Taken together, transcriptomic, epigenomic, and functional reprogramming of HSPCs and peripheral monocytes is a hallmark of BCG-induced trained immunity in humans. |BCG Vaccine/*immunology[MESH] |Bone Marrow Cells/cytology/immunology[MESH] |Bone Marrow/immunology[MESH] |Cytokines/metabolism[MESH] |Female[MESH] |Granulocytes/*cytology[MESH] |Healthy Volunteers[MESH] |Hematopoiesis/*immunology[MESH] |Hematopoietic Stem Cells/*cytology[MESH] |Hepatocyte Nuclear Factor 1-alpha/genetics[MESH] |Hepatocyte Nuclear Factor 1-beta/genetics[MESH] |Humans[MESH] |Lipopolysaccharide Receptors/metabolism[MESH] |Male[MESH] |Monocytes/*cytology/immunology[MESH] |Mycobacterium bovis/immunology[MESH] |Transcription, Genetic/genetics[MESH] |Transcriptome/genetics[MESH] |Vaccination[MESH] |Young Adult[MESH]BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoiet(epmc).pdf DeepDyve Pubget Overpricing