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10.1016/j.bbadis.2020.165878 http://scihub22266oqcxt.onion/10.1016/j.bbadis.2020.165878 32544429!7293463!32544429     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32544429&cmd=llinks): Failed to open stream: HTTP request failed! 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Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach |pdf=|usr=}}{{32544429}} gab.com Text Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach JO: Biochim Biophys Acta Mol Basis Dis http://www.kidney.de/pget.php?&tw=1&pmid=32544429 #FOAvip The sudden emergence of severe respiratory disease, caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently become a public health emergency. Genome sequence analysis of SARS-CoV-2 revealed its close resemblance to the earlier reported SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV). However, initial testing of the drugs used against SARS-CoV and MERS-CoV has been ineffective in controlling SARS-CoV-2. The present study highlights the genomic, proteomic, pathogenesis, and therapeutic strategies in SARS-CoV-2 infection. We have carried out sequence analysis of potential drug target proteins in SARS-CoV-2 and, compared them with SARS-CoV and MERS viruses. Analysis of mutations in the coding and non-coding regions, genetic diversity, and pathogenicity of SARS-CoV-2 has also been done. A detailed structural analysis of drug target proteins has been performed to gain insights into the mechanism of pathogenesis, structure-function relationships, and the development of structure-guided therapeutic approaches. The cytokine profiling and inflammatory signalling are different in the case of SARS-CoV-2 infection. We also highlighted possible therapies and their mechanism of action followed by clinical manifestation. Our analysis suggests a minimal variation in the genome sequence of SARS-CoV-2, may be responsible for a drastic change in the structures of target proteins, which makes available drugs ineffective. Twit Text FOAVip Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach ????Biochim Biophys Acta Mol Basis Dis http://www.kidney.de/pget.php?&tw=1&pmid=32544429 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32544429 #FOAvip English Wikipedia <ref>{{Cite pmid|32544429}}</ref> Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: Structural genomics approach #MMPMID32544429 Naqvi AAT; Fatima K; Mohammad T; Fatima U; Singh IK; Singh A; Atif SM; Hariprasad G; Hasan GM; Hassan MI Biochim Biophys Acta Mol Basis Dis 2020[Oct]; 1866 (10): 165878 PMID32544429show ga The sudden emergence of severe respiratory disease, caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently become a public health emergency. Genome sequence analysis of SARS-CoV-2 revealed its close resemblance to the earlier reported SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV). However, initial testing of the drugs used against SARS-CoV and MERS-CoV has been ineffective in controlling SARS-CoV-2. The present study highlights the genomic, proteomic, pathogenesis, and therapeutic strategies in SARS-CoV-2 infection. We have carried out sequence analysis of potential drug target proteins in SARS-CoV-2 and, compared them with SARS-CoV and MERS viruses. Analysis of mutations in the coding and non-coding regions, genetic diversity, and pathogenicity of SARS-CoV-2 has also been done. A detailed structural analysis of drug target proteins has been performed to gain insights into the mechanism of pathogenesis, structure-function relationships, and the development of structure-guided therapeutic approaches. The cytokine profiling and inflammatory signalling are different in the case of SARS-CoV-2 infection. We also highlighted possible therapies and their mechanism of action followed by clinical manifestation. Our analysis suggests a minimal variation in the genome sequence of SARS-CoV-2, may be responsible for a drastic change in the structures of target proteins, which makes available drugs ineffective. |*Genome, Viral[MESH] |Betacoronavirus/*genetics/isolation & purification/pathogenicity[MESH] |COVID-19[MESH] |Coronavirus Infections/drug therapy/pathology/virology[MESH] |Cytokines/metabolism[MESH] |Genetic Variation[MESH] |Humans[MESH] |Middle East Respiratory Syndrome Coronavirus/genetics/isolation & purification/pathogenicity[MESH] |Pandemics[MESH] |Pneumonia, Viral/drug therapy/pathology/virology[MESH] |RNA-Dependent RNA Polymerase/genetics[MESH] |SARS-CoV-2[MESH]Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis an(epmc).pdf DeepDyve Pubget Overpricing