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Lymphocyte Subset Counts in COVID-19 Patients: A Meta-Analysis #MMPMID32542842
Huang W; Berube J; McNamara M; Saksena S; Hartman M; Arshad T; Bornheimer SJ; O'Gorman M
Cytometry A 2020[Aug]; 97 (8): 772-776 PMID32542842show ga
A reduced peripheral blood absolute lymphocyte count with an elevated neutrophil count has been a consistent observation in hospitalized coronavirus disease 2019 (COVID-19) patients. In this brief meta-analysis, the reduction of lymphocyte subset counts in COVID-19 patients was investigated across 20 peer-reviewed studies meeting criteria for reporting lymphocyte subset counts and COVID-19 disease severity. CD4+ T cell, CD8+ T cell, B cell, NK cell, and total lymphocyte cell counts all showed statistically significant reduction in patients with severe/critical COVID-19 disease compared to mild/moderate disease. T-cell subsets showed the largest standardized magnitude of change. In some studies, multivariate analysis has shown that CD4 and/or CD8 T-cells counts are independently predictive of patient outcomes. (c) 2020 International Society for Advancement of Cytometry.