Rapid screening of COVID-19 patients using white blood cell scattergrams, a study on 381 patients #MMPMID32542672
Osman J; Lambert J; Temple M; Devaux F; Favre R; Flaujac C; Bridoux D; Marque-Juillet S; Bruneel F; Mignon F; Diaz-Flores E; Hentgen V; Greder-Belan A; Azarian R; Koukabi M; Rousselot P; Raggueneau V; Maneglier B
Br J Haematol 2020[Sep]; 190 (5): 718-722 PMID32542672show ga
Complementary tools are warranted to increase the sensitivity of the initial testing for COVID-19. We identified a specific 'sandglass' aspect on the white blood cell scattergram of COVID-19 patients reflecting the presence of circulating plasmacytoid lymphocytes. Patients were dichotomized as COVID-19-positive or -negative based on reverse transcriptase polymerase chain reaction (RT-PCR) and chest computed tomography (CT) scan results. Sensitivity and specificity of the 'sandglass' aspect were 85.9% and 83.5% respectively. The positive predictive value was 94.3%. Our findings provide a non-invasive and simple tool to quickly categorize symptomatic patients as either COVID-19-probable or -improbable especially when RT-PCR and/or chest CT are not rapidly available.
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Br+J+Haematol 2020 ; 190 (5): 718-722
