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10.1126/science.abd0831 http://scihub22266oqcxt.onion/10.1126/science.abd0831 32540904!7299283!32540904     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2020 ; 369 (6506): 1014-1018 Nephropedia Template TP {{tp|p=32540904|t=2020. Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies |pdf=|usr=}}{{32540904}} gab.com Text Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=32540904 #FOAvip Antibodies targeting the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) present a promising approach to combat the coronavirus disease 2019 (COVID-19) pandemic; however, concerns remain that mutations can yield antibody resistance. We investigated the development of resistance against four antibodies to the spike protein that potently neutralize SARS-CoV-2, individually as well as when combined into cocktails. These antibodies remain effective against spike variants that have arisen in the human population. However, novel spike mutants rapidly appeared after in vitro passaging in the presence of individual antibodies, resulting in loss of neutralization; such escape also occurred with combinations of antibodies binding diverse but overlapping regions of the spike protein. Escape mutants were not generated after treatment with a noncompeting antibody cocktail. Twit Text FOAVip Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies ????Science http://www.kidney.de/pget.php?&tw=1&pmid=32540904 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32540904 #FOAvip English Wikipedia <ref>{{Cite pmid|32540904}}</ref> Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies #MMPMID32540904 Baum A; Fulton BO; Wloga E; Copin R; Pascal KE; Russo V; Giordano S; Lanza K; Negron N; Ni M; Wei Y; Atwal GS; Murphy AJ; Stahl N; Yancopoulos GD; Kyratsous CA Science 2020[Aug]; 369 (6506): 1014-1018 PMID32540904show ga Antibodies targeting the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) present a promising approach to combat the coronavirus disease 2019 (COVID-19) pandemic; however, concerns remain that mutations can yield antibody resistance. We investigated the development of resistance against four antibodies to the spike protein that potently neutralize SARS-CoV-2, individually as well as when combined into cocktails. These antibodies remain effective against spike variants that have arisen in the human population. However, novel spike mutants rapidly appeared after in vitro passaging in the presence of individual antibodies, resulting in loss of neutralization; such escape also occurred with combinations of antibodies binding diverse but overlapping regions of the spike protein. Escape mutants were not generated after treatment with a noncompeting antibody cocktail. |Antibodies, Neutralizing/*immunology[MESH] |Antibodies, Viral/*immunology[MESH] |Betacoronavirus/chemistry/genetics/*immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology[MESH] |Epitopes[MESH] |Genome, Viral[MESH] |Humans[MESH] |Mutant Proteins/chemistry/immunology[MESH] |Mutation[MESH] |Neutralization Tests[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology[MESH] |Protein Interaction Domains and Motifs[MESH] |SARS-CoV-2[MESH] |Selection, Genetic[MESH]Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutationa(epmc).pdf DeepDyve Pubget Overpricing