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10.1126/science.abc7520 http://scihub22266oqcxt.onion/10.1126/science.abc7520 32540903!7299280!32540903     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2020 ; 369 (6506): 956-963 Nephropedia Template TP {{tp|p=32540903|t=2020. Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model |pdf=|usr=}}{{32540903}} gab.com Text Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=32540903 #FOAvip Countermeasures to prevent and treat coronavirus disease 2019 (COVID-19) are a global health priority. We enrolled a cohort of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-recovered participants, developed neutralization assays to investigate antibody responses, adapted our high-throughput antibody generation pipeline to rapidly screen more than 1800 antibodies, and established an animal model to test protection. We isolated potent neutralizing antibodies (nAbs) to two epitopes on the receptor binding domain (RBD) and to distinct non-RBD epitopes on the spike (S) protein. As indicated by maintained weight and low lung viral titers in treated animals, the passive transfer of a nAb provides protection against disease in high-dose SARS-CoV-2 challenge in Syrian hamsters. The study suggests a role for nAbs in prophylaxis, and potentially therapy, of COVID-19. The nAbs also define protective epitopes to guide vaccine design. Twit Text FOAVip Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model ????Science http://www.kidney.de/pget.php?&tw=1&pmid=32540903 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32540903 #FOAvip English Wikipedia <ref>{{Cite pmid|32540903}}</ref> Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model #MMPMID32540903 Rogers TF; Zhao F; Huang D; Beutler N; Burns A; He WT; Limbo O; Smith C; Song G; Woehl J; Yang L; Abbott RK; Callaghan S; Garcia E; Hurtado J; Parren M; Peng L; Ramirez S; Ricketts J; Ricciardi MJ; Rawlings SA; Wu NC; Yuan M; Smith DM; Nemazee D; Teijaro JR; Voss JE; Wilson IA; Andrabi R; Briney B; Landais E; Sok D; Jardine JG; Burton DR Science 2020[Aug]; 369 (6506): 956-963 PMID32540903show ga Countermeasures to prevent and treat coronavirus disease 2019 (COVID-19) are a global health priority. We enrolled a cohort of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-recovered participants, developed neutralization assays to investigate antibody responses, adapted our high-throughput antibody generation pipeline to rapidly screen more than 1800 antibodies, and established an animal model to test protection. We isolated potent neutralizing antibodies (nAbs) to two epitopes on the receptor binding domain (RBD) and to distinct non-RBD epitopes on the spike (S) protein. As indicated by maintained weight and low lung viral titers in treated animals, the passive transfer of a nAb provides protection against disease in high-dose SARS-CoV-2 challenge in Syrian hamsters. The study suggests a role for nAbs in prophylaxis, and potentially therapy, of COVID-19. The nAbs also define protective epitopes to guide vaccine design. |*Antibodies, Monoclonal/blood/immunology/isolation & purification/therapeutic use[MESH] |*Antibodies, Neutralizing/blood/immunology/isolation & purification/therapeutic use[MESH] |*Antibodies, Viral/blood/immunology/isolation & purification/therapeutic use[MESH] |Adult[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Antibody Affinity[MESH] |Antibody Specificity[MESH] |Betacoronavirus/*immunology/physiology[MESH] |Binding Sites[MESH] |COVID-19[MESH] |COVID-19 Serotherapy[MESH] |Cell Line[MESH] |Coronavirus Infections/*immunology/*prevention & control/therapy/virology[MESH] |Disease Models, Animal[MESH] |Epitopes[MESH] |Female[MESH] |Humans[MESH] |Immunization, Passive[MESH] |Lung/virology[MESH] |Male[MESH] |Mesocricetus[MESH] |Middle Aged[MESH] |Neutralization Tests[MESH] |Pandemics/*prevention & control[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Pneumonia, Viral/*immunology/*prevention & control/therapy/virology[MESH] |Protein Domains[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/chemistry/immunology/metabolism[MESH] |Viral Load[MESH]Isolation of potent SARS-CoV-2 neutralizing antibodies and protection (epmc).pdf DeepDyve Pubget Overpricing