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10.1126/science.abd0827 http://scihub22266oqcxt.onion/10.1126/science.abd0827 32540901!7299284!32540901     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2020 ; 369 (6506): 1010-1014 Nephropedia Template TP {{tp|p=32540901|t=2020. Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail |pdf=|usr=}}{{32540901}} gab.com Text Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=32540901 #FOAvip Neutralizing antibodies have become an important tool in treating infectious diseases. Recently, two separate approaches yielded successful antibody treatments for Ebola-one from genetically humanized mice and the other from a human survivor. Here, we describe parallel efforts using both humanized mice and convalescent patients to generate antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, which yielded a large collection of fully human antibodies that were characterized for binding, neutralization, and three-dimensional structure. On the basis of these criteria, we selected pairs of highly potent individual antibodies that simultaneously bind the receptor binding domain of the spike protein, thereby providing ideal partners for a therapeutic antibody cocktail that aims to decrease the potential for virus escape mutants that might arise in response to selective pressure from a single-antibody treatment. Twit Text FOAVip Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail ????Science http://www.kidney.de/pget.php?&tw=1&pmid=32540901 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32540901 #FOAvip English Wikipedia <ref>{{Cite pmid|32540901}}</ref> Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail #MMPMID32540901 Hansen J; Baum A; Pascal KE; Russo V; Giordano S; Wloga E; Fulton BO; Yan Y; Koon K; Patel K; Chung KM; Hermann A; Ullman E; Cruz J; Rafique A; Huang T; Fairhurst J; Libertiny C; Malbec M; Lee WY; Welsh R; Farr G; Pennington S; Deshpande D; Cheng J; Watty A; Bouffard P; Babb R; Levenkova N; Chen C; Zhang B; Romero Hernandez A; Saotome K; Zhou Y; Franklin M; Sivapalasingam S; Lye DC; Weston S; Logue J; Haupt R; Frieman M; Chen G; Olson W; Murphy AJ; Stahl N; Yancopoulos GD; Kyratsous CA Science 2020[Aug]; 369 (6506): 1010-1014 PMID32540901show ga Neutralizing antibodies have become an important tool in treating infectious diseases. Recently, two separate approaches yielded successful antibody treatments for Ebola-one from genetically humanized mice and the other from a human survivor. Here, we describe parallel efforts using both humanized mice and convalescent patients to generate antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, which yielded a large collection of fully human antibodies that were characterized for binding, neutralization, and three-dimensional structure. On the basis of these criteria, we selected pairs of highly potent individual antibodies that simultaneously bind the receptor binding domain of the spike protein, thereby providing ideal partners for a therapeutic antibody cocktail that aims to decrease the potential for virus escape mutants that might arise in response to selective pressure from a single-antibody treatment. |Adolescent[MESH] |Adult[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Antibodies, Neutralizing/chemistry/*immunology[MESH] |Antibodies, Viral/chemistry/*immunology[MESH] |Antibody Affinity[MESH] |Antibody-Dependent Cell Cytotoxicity[MESH] |Betacoronavirus/chemistry/*immunology[MESH] |Binding Sites, Antibody[MESH] |Broadly Neutralizing Antibodies/chemistry/immunology[MESH] |COVID-19[MESH] |COVID-19 Serotherapy[MESH] |Cell Line[MESH] |Coronavirus Infections/*immunology/therapy[MESH] |Cytophagocytosis[MESH] |Epitopes[MESH] |Humans[MESH] |Immunization, Passive[MESH] |Mice[MESH] |Middle Aged[MESH] |Models, Molecular[MESH] |Neutralization Tests[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Pneumonia, Viral/*immunology[MESH] |Protein Interaction Domains and Motifs[MESH] |Receptors, Coronavirus[MESH] |Receptors, Virus/metabolism[MESH] |SARS-CoV-2[MESH] |Severe acute respiratory syndrome-related coronavirus/immunology[MESH] |Spike Glycoprotein, Coronavirus/chemistry/*immunology/metabolism[MESH]Studies in humanized mice and convalescent humans yield a SARS-CoV-2 a(epmc).pdf DeepDyve Pubget Overpricing