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10.1126/science.abc7424 http://scihub22266oqcxt.onion/10.1126/science.abc7424 32540900!7299279!32540900     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2020 ; 369 (6504): 731-736 Nephropedia Template TP {{tp|p=32540900|t=2020. Broad neutralization of SARS-related viruses by human monoclonal antibodies |pdf=|usr=}}{{32540900}} gab.com Text Broad neutralization of SARS-related viruses by human monoclonal antibodies JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=32540900 #FOAvip Broadly protective vaccines against known and preemergent human coronaviruses (HCoVs) are urgently needed. To gain a deeper understanding of cross-neutralizing antibody responses, we mined the memory B cell repertoire of a convalescent severe acute respiratory syndrome (SARS) donor and identified 200 SARS coronavirus 2 (SARS-CoV-2) binding antibodies that target multiple conserved sites on the spike (S) protein. A large proportion of the non-neutralizing antibodies display high levels of somatic hypermutation and cross-react with circulating HCoVs, suggesting recall of preexisting memory B cells elicited by prior HCoV infections. Several antibodies potently cross-neutralize SARS-CoV, SARS-CoV-2, and the bat SARS-like virus WIV1 by blocking receptor attachment and inducing S1 shedding. These antibodies represent promising candidates for therapeutic intervention and reveal a target for the rational design of pan-sarbecovirus vaccines. Twit Text FOAVip Broad neutralization of SARS-related viruses by human monoclonal antibodies ????Science http://www.kidney.de/pget.php?&tw=1&pmid=32540900 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32540900 #FOAvip English Wikipedia <ref>{{Cite pmid|32540900}}</ref> Broad neutralization of SARS-related viruses by human monoclonal antibodies #MMPMID32540900 Wec AZ; Wrapp D; Herbert AS; Maurer DP; Haslwanter D; Sakharkar M; Jangra RK; Dieterle ME; Lilov A; Huang D; Tse LV; Johnson NV; Hsieh CL; Wang N; Nett JH; Champney E; Burnina I; Brown M; Lin S; Sinclair M; Johnson C; Pudi S; Bortz R 3rd; Wirchnianski AS; Laudermilch E; Florez C; Fels JM; O'Brien CM; Graham BS; Nemazee D; Burton DR; Baric RS; Voss JE; Chandran K; Dye JM; McLellan JS; Walker LM Science 2020[Aug]; 369 (6504): 731-736 PMID32540900show ga Broadly protective vaccines against known and preemergent human coronaviruses (HCoVs) are urgently needed. To gain a deeper understanding of cross-neutralizing antibody responses, we mined the memory B cell repertoire of a convalescent severe acute respiratory syndrome (SARS) donor and identified 200 SARS coronavirus 2 (SARS-CoV-2) binding antibodies that target multiple conserved sites on the spike (S) protein. A large proportion of the non-neutralizing antibodies display high levels of somatic hypermutation and cross-react with circulating HCoVs, suggesting recall of preexisting memory B cells elicited by prior HCoV infections. Several antibodies potently cross-neutralize SARS-CoV, SARS-CoV-2, and the bat SARS-like virus WIV1 by blocking receptor attachment and inducing S1 shedding. These antibodies represent promising candidates for therapeutic intervention and reveal a target for the rational design of pan-sarbecovirus vaccines. |Adult[MESH] |Aged[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Antibodies, Monoclonal/*immunology[MESH] |Antibodies, Viral/*immunology[MESH] |Antibody Affinity[MESH] |B-Lymphocyte Subsets/immunology[MESH] |Betacoronavirus/*immunology[MESH] |Binding Sites[MESH] |Broadly Neutralizing Antibodies/*immunology[MESH] |Cross Reactions[MESH] |Epitopes[MESH] |Female[MESH] |Humans[MESH] |Immunologic Memory[MESH] |Male[MESH] |Middle Aged[MESH] |Neutralization Tests[MESH] |Peptidyl-Dipeptidase A/chemistry/metabolism[MESH] |Protein Domains[MESH] |Receptors, Coronavirus[MESH] |Receptors, Virus/chemistry/metabolism[MESH] |SARS-CoV-2[MESH] |Severe Acute Respiratory Syndrome/immunology[MESH] |Severe acute respiratory syndrome-related coronavirus/*immunology[MESH] |Somatic Hypermutation, Immunoglobulin[MESH] |Spike Glycoprotein, Coronavirus/chemistry/*immunology/metabolism[MESH]Broad neutralization of SARS-related viruses by human monoclonal antib(epmc).pdf DeepDyve Pubget Overpricing