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10.1016/j.mehy.2020.109988 http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.109988 32540603!7282759!32540603     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med+Hypotheses 2020 ; 144 (ä): 109988 Nephropedia Template TP {{tp|p=32540603|t=2020. Repositioning of pentoxifylline as an immunomodulator and regulator of the renin-angiotensin system in the treatment of COVID-19 |pdf=|usr=}}{{32540603}} gab.com Text Repositioning of pentoxifylline as an immunomodulator and regulator of the renin-angiotensin system in the treatment of COVID-19 JO: Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32540603 #FOAvip Pentoxifylline (PTX) is a phosphodiesterase inhibitor that increases cyclic adenosine monophosphate levels, which in turn activate protein kinase, leading to a reduction in the synthesis of proinflammatory cytokines to ultimately influence the renin-angiotensin system (RAS) in vitro by inhibiting angiotensin 1 receptor (AT1R) expression. The rheological, anti-inflammatory, and renin-angiotensin axis properties of PTX highlight this drug as a therapeutic treatment alternative for patients with COVID-19 by helping reduce the production of the inflammatory cytokines without deleterious effects on the immune system to delay viral clearance. Moreover, PTX can restore the balance of the immune response, reduce damage to the endothelium and alveolar epithelial cells, improve circulation, and prevent microvascular thrombosis. There is further evidence that PTX can improve ventilatory parameters. Therefore, we propose repositioning PTX in the treatment of COVID-19. The main advantage of repositioning PTX is that it is an affordable drug that is already available worldwide with an established safety profile, further offering the possibility of immediately analysing the result of its use and associated success rates. Another advantage is that PTX selectively reduces the concentration of TNF-alpha mRNA in cells, which, in the case of an acute infectious state such as COVID-19, would seem to offer a more strategic approach. Twit Text FOAVip Repositioning of pentoxifylline as an immunomodulator and regulator of the renin-angiotensin system in the treatment of COVID-19 ????Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32540603 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32540603 #FOAvip English Wikipedia <ref>{{Cite pmid|32540603}}</ref> Repositioning of pentoxifylline as an immunomodulator and regulator of the renin-angiotensin system in the treatment of COVID-19 #MMPMID32540603 Maldonado V; Loza-Mejia MA; Chavez-Alderete J Med Hypotheses 2020[Nov]; 144 (ä): 109988 PMID32540603show ga Pentoxifylline (PTX) is a phosphodiesterase inhibitor that increases cyclic adenosine monophosphate levels, which in turn activate protein kinase, leading to a reduction in the synthesis of proinflammatory cytokines to ultimately influence the renin-angiotensin system (RAS) in vitro by inhibiting angiotensin 1 receptor (AT1R) expression. The rheological, anti-inflammatory, and renin-angiotensin axis properties of PTX highlight this drug as a therapeutic treatment alternative for patients with COVID-19 by helping reduce the production of the inflammatory cytokines without deleterious effects on the immune system to delay viral clearance. Moreover, PTX can restore the balance of the immune response, reduce damage to the endothelium and alveolar epithelial cells, improve circulation, and prevent microvascular thrombosis. There is further evidence that PTX can improve ventilatory parameters. Therefore, we propose repositioning PTX in the treatment of COVID-19. The main advantage of repositioning PTX is that it is an affordable drug that is already available worldwide with an established safety profile, further offering the possibility of immediately analysing the result of its use and associated success rates. Another advantage is that PTX selectively reduces the concentration of TNF-alpha mRNA in cells, which, in the case of an acute infectious state such as COVID-19, would seem to offer a more strategic approach. |*COVID-19 Drug Treatment[MESH] |*Drug Repositioning[MESH] |*Pandemics[MESH] |Alveolar Epithelial Cells/drug effects[MESH] |Angiotensin II/physiology[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |Animals[MESH] |COVID-19/epidemiology/immunology/physiopathology[MESH] |Complement Activation/drug effects[MESH] |Cytokines/biosynthesis/genetics[MESH] |Disease Models, Animal[MESH] |Endothelial Cells/drug effects[MESH] |Gene Expression Regulation/drug effects[MESH] |Humans[MESH] |Immunologic Factors/pharmacology/*therapeutic use[MESH] |Inflammation[MESH] |Lymphocyte Subsets/drug effects[MESH] |Microcirculation/drug effects[MESH] |Oxidative Stress[MESH] |Pentoxifylline/pharmacology/*therapeutic use[MESH] |Rats[MESH] |Receptors, Virus/metabolism[MESH] |Renin-Angiotensin System/*drug effects/physiology[MESH] |SARS-CoV-2/*physiology[MESH] |Signal Transduction/drug effects[MESH]Repositioning of pentoxifylline as an immunomodulator and regulator of(epmc).pdf DeepDyve Pubget Overpricing