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10.1177/1753466620933508 http://scihub22266oqcxt.onion/10.1177/1753466620933508 32539627!7298425!32539627     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ther+Adv+Respir+Dis 2020 ; 14 (ä): 1753466620933508 Nephropedia Template TP {{tp|p=32539627|t=2020. Lung under attack by COVID-19-induced cytokine storm: pathogenic mechanisms and therapeutic implications |pdf=|usr=}}{{32539627}} gab.com Text Lung under attack by COVID-19-induced cytokine storm: pathogenic mechanisms and therapeutic implications JO: Ther Adv Respir Dis http://www.kidney.de/pget.php?&tw=1&pmid=32539627 #FOAvip The lung is a key target of the cytokine storm that can be triggered by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), responsible for the widespread clinical syndrome known as coronavirus disease 2019 (COVID-19). Indeed, in some patients, SARS-CoV-2 promotes a dysfunctional immune response that dysregulates the cytokine secretory pattern. Hypercytokinemia underlies the hyperinflammatory state leading to injury of alveolar epithelial cells and vascular endothelial cells, as well as to lung infiltration sustained by neutrophils and macrophages. Within such a pathogenic context, interleukin-6 (IL-6) and other cytokines/chemokines play a pivotal pro-inflammatory role. Therefore, cytokines and their receptors, as well as cytokine-dependent intracellular signalling pathways can be targeted by potential therapies aimed to relieve the heavy burden of cytokine storm. In particular, the anti-IL-6-receptor monoclonal antibody tocilizumab is emerging as one of the most promising pharmacologic treatments. The reviews of this paper are available via the supplemental material section. Twit Text FOAVip Lung under attack by COVID-19-induced cytokine storm: pathogenic mechanisms and therapeutic implications ????Ther Adv Respir Dis http://www.kidney.de/pget.php?&tw=1&pmid=32539627 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32539627 #FOAvip English Wikipedia <ref>{{Cite pmid|32539627}}</ref> Lung under attack by COVID-19-induced cytokine storm: pathogenic mechanisms and therapeutic implications #MMPMID32539627 Pelaia C; Tinello C; Vatrella A; De Sarro G; Pelaia G Ther Adv Respir Dis 2020[Jan]; 14 (ä): 1753466620933508 PMID32539627show ga The lung is a key target of the cytokine storm that can be triggered by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), responsible for the widespread clinical syndrome known as coronavirus disease 2019 (COVID-19). Indeed, in some patients, SARS-CoV-2 promotes a dysfunctional immune response that dysregulates the cytokine secretory pattern. Hypercytokinemia underlies the hyperinflammatory state leading to injury of alveolar epithelial cells and vascular endothelial cells, as well as to lung infiltration sustained by neutrophils and macrophages. Within such a pathogenic context, interleukin-6 (IL-6) and other cytokines/chemokines play a pivotal pro-inflammatory role. Therefore, cytokines and their receptors, as well as cytokine-dependent intracellular signalling pathways can be targeted by potential therapies aimed to relieve the heavy burden of cytokine storm. In particular, the anti-IL-6-receptor monoclonal antibody tocilizumab is emerging as one of the most promising pharmacologic treatments. The reviews of this paper are available via the supplemental material section. |*Betacoronavirus[MESH] |*Immunity, Innate[MESH] |Antibodies, Monoclonal, Humanized/*therapeutic use[MESH] |COVID-19[MESH] |Coronavirus Infections/drug therapy/*immunology/metabolism[MESH] |Cytokines/*immunology/metabolism[MESH] |Endothelial Cells/metabolism[MESH] |Humans[MESH] |Lung/*metabolism[MESH] |Pandemics[MESH] |Pneumonia, Viral/drug therapy/*immunology/metabolism[MESH]Lung under attack by COVID-19-induced cytokine storm: pathogenic mecha(epmc).pdf DeepDyve Pubget Overpricing