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10.3947/ic.2020.52.3.335 http://scihub22266oqcxt.onion/10.3947/ic.2020.52.3.335 32537960!7533209!32537960     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Infect+Chemother 2020 ; 52 (3): 335-344 Nephropedia Template TP {{tp|p=32537960|t=2020. A Pathophysiological Perspective on COVID-19 s Lethal Complication: From Viremia to Hypersensitivity Pneumonitis-like Immune Dysregulation |pdf=|usr=}}{{32537960}} gab.com Text A Pathophysiological Perspective on COVID-19 s Lethal Complication: From Viremia to Hypersensitivity Pneumonitis-like Immune Dysregulation JO: Infect Chemother http://www.kidney.de/pget.php?&tw=1&pmid=32537960 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the coronavirus responsible for our recent coronavirus disease 2019 pandemic, is driving a lung immunopathology that strongly resembles a severe form of hypersensitivity pneumonitis (HP). A review of recent Severe acute respiratory syndrome-related coronavirus (SARS-CoV) and SARS-CoV-2 medical reports, as well as described characteristics of HP, lead us to postulate a theory for SARS-CoV-2 severe disease. We propose that the novel SARS-CoV-2 can act as a trigger and substrate of an HP-like severe immune reaction especially in genetically vulnerable individuals in addition to those with immune senescence and dysregulation. Accordingly, the purpose of our letter is to shift the emphasis of concern surrounding immune activity from viral infection to an HP-like severe immune reaction. We review similarities in disease presentation between infection and allergy, relevant immunopathology, and outline phases of SARS-CoV-2 disease with perspectives on therapy and critical care. Altogether, the favored course is to begin treatments that address the disease at the earliest phase before immune dysregulation leading to uncontrolled pulmonary inflammation. Twit Text FOAVip A Pathophysiological Perspective on COVID-19 s Lethal Complication: From Viremia to Hypersensitivity Pneumonitis-like Immune Dysregulation ????Infect Chemother http://www.kidney.de/pget.php?&tw=1&pmid=32537960 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32537960 #FOAvip English Wikipedia <ref>{{Cite pmid|32537960}}</ref> A Pathophysiological Perspective on COVID-19 s Lethal Complication: From Viremia to Hypersensitivity Pneumonitis-like Immune Dysregulation #MMPMID32537960 Sanchez-Gonzalez MA; Moskowitz D; Issuree PD; Yatzkan G; Rizvi SAA; Day K Infect Chemother 2020[Sep]; 52 (3): 335-344 PMID32537960show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the coronavirus responsible for our recent coronavirus disease 2019 pandemic, is driving a lung immunopathology that strongly resembles a severe form of hypersensitivity pneumonitis (HP). A review of recent Severe acute respiratory syndrome-related coronavirus (SARS-CoV) and SARS-CoV-2 medical reports, as well as described characteristics of HP, lead us to postulate a theory for SARS-CoV-2 severe disease. We propose that the novel SARS-CoV-2 can act as a trigger and substrate of an HP-like severe immune reaction especially in genetically vulnerable individuals in addition to those with immune senescence and dysregulation. Accordingly, the purpose of our letter is to shift the emphasis of concern surrounding immune activity from viral infection to an HP-like severe immune reaction. We review similarities in disease presentation between infection and allergy, relevant immunopathology, and outline phases of SARS-CoV-2 disease with perspectives on therapy and critical care. Altogether, the favored course is to begin treatments that address the disease at the earliest phase before immune dysregulation leading to uncontrolled pulmonary inflammation. äA Pathophysiological Perspective on COVID-19 s Lethal Complication: Fr(epmc).pdf DeepDyve Pubget Overpricing