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  • A compendium answering 150 questions on COVID-19 and SARS-CoV-2 #MMPMID32535955
  • Riggioni C; Comberiati P; Giovannini M; Agache I; Akdis M; Alves-Correia M; Anto JM; Arcolaci A; Azkur AK; Azkur D; Beken B; Boccabella C; Bousquet J; Breiteneder H; Carvalho D; De Las Vecillas L; Diamant Z; Eguiluz-Gracia I; Eiwegger T; Eyerich S; Fokkens W; Gao YD; Hannachi F; Johnston SL; Jutel M; Karavelia A; Klimek L; Moya B; Nadeau KC; O'Hehir R; O'Mahony L; Pfaar O; Sanak M; Schwarze J; Sokolowska M; Torres MJ; van de Veen W; van Zelm MC; Wang Y; Zhang L; Jimenez-Saiz R; Akdis CA
  • Allergy 2020[Oct]; 75 (10): 2503-2541 PMID32535955show ga
  • In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date, it has resulted in ~9 million confirmed cases and caused almost 500 000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socioeconomic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a "cytokine storm" leading to acute respiratory distress syndrome, endothelitis, thromboembolic complications, and multiorgan failure. The epidemiologic features of COVID-19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID-19-related topics should be based on more coordinated high-quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS-CoV-2, COVID-19, and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development, and epidemiology. A total of 150 questions were answered by experts in the field providing a comprehensive and practical overview of COVID-19 and allergic disease.
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  • suck abstract from ncbi

    2503 10.75 2020