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10.1016/j.mehy.2020.109905

http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.109905
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suck abstract from ncbi


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pmid32535456      Med+Hypotheses 2020 ; 144 (ä): 109905
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  • Natural RNA dependent RNA polymerase inhibitors: Molecular docking studies of some biologically active alkaloids of Argemone mexicana #MMPMID32535456
  • Pandeya KB; Ganeshpurkar A; Mishra MK
  • Med Hypotheses 2020[Nov]; 144 (ä): 109905 PMID32535456show ga
  • COVID-19 has become disastrous for world and spread all over. Researchers all around the globe are working to discover a drug to cure from COVID-19. RNA dependent RNA polymerase plays a key role in SARS-CoV-2 replication and thus it could be a potential target for SARS-CoV-2. This study revealed that Protopine, Allocryptopine and (+/-) 6- Acetonyldihydrochelerythrine could be potential RdRp inhibitors of SARS-CoV-2.
  • |*COVID-19 Drug Treatment[MESH]
  • |Antiviral Agents/pharmacology[MESH]
  • |Argemone/*chemistry[MESH]
  • |Benzophenanthridines/*pharmacology[MESH]
  • |Berberine Alkaloids/*pharmacology[MESH]
  • |Computer Simulation[MESH]
  • |Drug Repositioning[MESH]
  • |Humans[MESH]
  • |Molecular Conformation[MESH]
  • |Molecular Docking Simulation[MESH]
  • |Phenanthrenes/pharmacology[MESH]
  • |Phytochemicals/pharmacology[MESH]
  • |Plant Extracts/*therapeutic use[MESH]
  • |RNA-Dependent RNA Polymerase/*antagonists & inhibitors[MESH]


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