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10.1016/j.ijid.2020.06.026

http://scihub22266oqcxt.onion/10.1016/j.ijid.2020.06.026
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suck abstract from ncbi


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pmid32535301      Int+J+Infect+Dis 2020 ; 98 (ä): 80-83
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  • Comparison of hospitalized patients with pneumonia caused by COVID-19 and influenza A in children under 5 years #MMPMID32535301
  • Li Y; Wang H; Wang F; Du H; Liu X; Chen P; Wang Y; Lu X
  • Int J Infect Dis 2020[Sep]; 98 (ä): 80-83 PMID32535301show ga
  • BACKGROUND: Since the outbreak of Coronavirus Disease 2019 (COVID-19) in Wuhan, considerable attention has been paid to its epidemiology and clinical characteristics in children. However, it is also crucial for clinicians to differentiate COVID-19 from other respiratory infectious diseases, such as influenza viruses. METHODS: This was a retrospective study. Two groups of COVID-19 patients (n=57) and influenza A patients (n=59) were enrolled. We analyzed and compared their clinical manifestations, imaging characteristics and treatments. RESULTS: The proportions of cough (70.2%), fever (54.4%) and gastrointestinal symptoms (14.1%) in COVID-19 patients were lower than those of influenza A patients (98.3%, P<0.001; 84.7%, P<0.001; and 35.6%, P=0.007; respectively). In addition, COVID-19 patients showed significantly lower levels of leukocytes (7.87 vs. 9.89x10(9)L(-1), P=0.027), neutrophils (2.43 vs. 5.16x10(9)L(-1), P<0.001), C-reactive protein (CRP; 3.7 vs. 15.1mg/L, P=0.001) and procalcitonin (PCT; 0.09 vs. 0.68mm/h, P<0.001), while lymphocyte levels (4.58 vs. 3.56x109L(-1); P=0.006) were significantly higher compared with influenza A patients. In terms of CT imaging, ground-glass opacification in chest CT was more common in COVID-19 patients than in influenza A patients (42.1% vs. 15%, P=0.032). In contrast, consolidation was more common in influenza A patients (25%) than in COVID-19 patients (5.2%, P=0.025). CONCLUSION: The clinical manifestations and laboratory tests of COVID-19 children are milder than those of influenza A children under 5 years. Additionally, imaging results more commonly presented as ground-glass opacities in COVID-19 patients.
  • |*Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Child, Preschool[MESH]
  • |Coronavirus Infections/complications/*diagnostic imaging/epidemiology[MESH]
  • |Cough/etiology[MESH]
  • |Female[MESH]
  • |Fever/etiology[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Influenza, Human/complications/*diagnostic imaging/epidemiology[MESH]
  • |Male[MESH]
  • |Neutrophils[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/complications/*diagnostic imaging/epidemiology[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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