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10.1016/j.hrthm.2020.06.009

http://scihub22266oqcxt.onion/10.1016/j.hrthm.2020.06.009
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suck abstract from ncbi


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pmid32535142      Heart+Rhythm 2020 ; 17 (9): 1434-1438
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  • Behavior of the PR interval with increasing heart rate in patients with COVID-19 #MMPMID32535142
  • Pavri BB; Kloo J; Farzad D; Riley JM
  • Heart Rhythm 2020[Sep]; 17 (9): 1434-1438 PMID32535142show ga
  • BACKGROUND: Myriad manifestations of cardiovascular involvement have been described in patients with coronavirus disease 2019 (COVID-19), but there have been no reports of COVID-19 affecting the cardiac conduction system. The PR interval on the electrocardiogram (ECG) normally shortens with increasing heart rate (HR). The case of a patient with COVID-19 manifesting Mobitz type 1 atrioventricular (AV) block that normalized as the patient's condition improved prompted us to investigate PR interval behavior in patients with COVID-19. OBJECTIVE: The purpose of this study was to characterize PR interval behavior in hospitalized patients with COVID-19 and to correlate that behavior with clinical outcomes. METHODS: This study was a cross-sectional cohort analysis of confirmed COVID-19 cases (March 26, 2020, to April 25, 2020). We reviewed pre-COVID-19 and COVID-19 ECGs to characterize AV conduction by calculating the PR interval to HR (PR:HR) slope. Clinical endpoints were death or need for endotracheal intubation. RESULTS: ECGs from 75 patients (246 pre-COVID-19 ECGs and 246 COVID-19 ECGs) were analyzed for PR:HR slope. Of these patients, 38 (50.7%) showed the expected PR interval shortening with increasing HR (negative PR:HR slope), whereas 37 (49.3%) showed either no change (8 with PR:HR slope = 0) or paradoxical PR interval prolongation (29 with positive PR:HR slope) with increasing HR. Patients without PR interval shortening were more likely to die (11/37 [29.7%] vs 3/38 [7.9%]; P = .019) or require endotracheal intubation (16/37 [43.2%] vs 8/38 [21.1%]; P = .05) compared to patients with PR interval shortening. CONCLUSION: Half of patients with COVID-19 showed abnormal PR interval behavior (paradoxical prolongation or lack of shortening) with increasing HR. This finding was associated with increased risk of death and need for endotracheal intubation.
  • |*Betacoronavirus[MESH]
  • |Aged[MESH]
  • |Arrhythmias, Cardiac/diagnosis/*epidemiology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*complications/*physiopathology[MESH]
  • |Electrocardiography[MESH]
  • |Female[MESH]
  • |Heart Conduction System/*physiopathology[MESH]
  • |Heart Rate/*physiology[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/*physiopathology[MESH]
  • |Retrospective Studies[MESH]


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