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10.1016/j.bcp.2020.114096 http://scihub22266oqcxt.onion/10.1016/j.bcp.2020.114096 32535105!7290223!32535105     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32535105&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Pharmacol 2020 ; 181 (ä): 114096 Nephropedia Template TP {{tp|p=32535105|t=2020. Animal toxins - Nature s evolutionary-refined toolkit for basic research and drug discovery |pdf=|usr=}}{{32535105}} gab.com Text Animal toxins - Nature s evolutionary-refined toolkit for basic research and drug discovery JO: Biochem Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32535105 #FOAvip Venomous animals have evolved toxins that interfere with specific components of their victim's core physiological systems, thereby causing biological dysfunction that aids in prey capture, defense against predators, or other roles such as intraspecific competition. Many animal lineages evolved venom systems independently, highlighting the success of this strategy. Over the course of evolution, toxins with exceptional specificity and high potency for their intended molecular targets have prevailed, making venoms an invaluable and almost inexhaustible source of bioactive molecules, some of which have found use as pharmacological tools, human therapeutics, and bioinsecticides. Current biomedically-focused research on venoms is directed towards their use in delineating the physiological role of toxin molecular targets such as ion channels and receptors, studying or treating human diseases, targeting vectors of human diseases, and treating microbial and parasitic infections. We provide examples of each of these areas of venom research, highlighting the potential that venom molecules hold for basic research and drug development. Twit Text FOAVip Animal toxins - Nature s evolutionary-refined toolkit for basic research and drug discovery ????Biochem Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32535105 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32535105 #FOAvip English Wikipedia <ref>{{Cite pmid|32535105}}</ref> Animal toxins - Nature s evolutionary-refined toolkit for basic research and drug discovery #MMPMID32535105 Herzig V; Cristofori-Armstrong B; Israel MR; Nixon SA; Vetter I; King GF Biochem Pharmacol 2020[Nov]; 181 (ä): 114096 PMID32535105show ga Venomous animals have evolved toxins that interfere with specific components of their victim's core physiological systems, thereby causing biological dysfunction that aids in prey capture, defense against predators, or other roles such as intraspecific competition. Many animal lineages evolved venom systems independently, highlighting the success of this strategy. Over the course of evolution, toxins with exceptional specificity and high potency for their intended molecular targets have prevailed, making venoms an invaluable and almost inexhaustible source of bioactive molecules, some of which have found use as pharmacological tools, human therapeutics, and bioinsecticides. Current biomedically-focused research on venoms is directed towards their use in delineating the physiological role of toxin molecular targets such as ion channels and receptors, studying or treating human diseases, targeting vectors of human diseases, and treating microbial and parasitic infections. We provide examples of each of these areas of venom research, highlighting the potential that venom molecules hold for basic research and drug development. |Animals[MESH] |Biomedical Research/*methods[MESH] |Drug Development/methods[MESH] |Drug Discovery/*methods[MESH] |Humans[MESH] |Molecular Targeted Therapy/methods[MESH] |Peptides/chemistry/*pharmacology/therapeutic use[MESH] |Protein Conformation[MESH] |Toxins, Biological/chemistry/*pharmacology/therapeutic use[MESH]Animal toxins - Nature s evolutionary-refined toolkit for basic resear(epmc).pdf DeepDyve Pubget Overpricing