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10.1016/j.jsbmb.2020.105719

http://scihub22266oqcxt.onion/10.1016/j.jsbmb.2020.105719
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suck abstract from ncbi


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pmid32535032      J+Steroid+Biochem+Mol+Biol 2020 ; 202 (ä): 105719
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  • Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections: Revised Ms SBMB 2020_166 #MMPMID32535032
  • Quesada-Gomez JM; Entrenas-Castillo M; Bouillon R
  • J Steroid Biochem Mol Biol 2020[Sep]; 202 (ä): 105719 PMID32535032show ga
  • Coronavirus infection is a serious health problem awaiting an effective vaccine and/or antiviral treatment. The major complication of coronavirus disease 2019 (COVID-19), the Acute Respiratory Distress syndrome (ARDS), is due to a variety of mechanisms including cytokine storm, dysregulation of the renin-angiotensin system, neutrophil activation and increased (micro)coagulation. Based on many preclinical studies and observational data in humans, ARDS may be aggravated by vitamin D deficiency and tapered down by activation of the vitamin D receptor. Several randomized clinical trials using either oral vitamin D or oral Calcifediol (25OHD) are ongoing. Based on a pilot study, oral calcifediol may be the most promising approach. These studies are expected to provide guidelines within a few months.
  • |Administration, Oral[MESH]
  • |Betacoronavirus/drug effects[MESH]
  • |COVID-19[MESH]
  • |Calcifediol/administration & dosage/*therapeutic use[MESH]
  • |Coronavirus Infections/complications/*drug therapy/pathology[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pilot Projects[MESH]
  • |Pneumonia, Viral/complications/*drug therapy/pathology[MESH]
  • |Randomized Controlled Trials as Topic[MESH]
  • |Renin-Angiotensin System/drug effects[MESH]
  • |Respiratory Distress Syndrome/complications/*drug therapy/pathology[MESH]
  • |SARS-CoV-2[MESH]
  • |Vitamin D Deficiency/complications/drug therapy/pathology[MESH]
  • |Vitamin D/administration & dosage/*therapeutic use[MESH]


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