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10.1016/j.diabres.2020.108267 http://scihub22266oqcxt.onion/10.1016/j.diabres.2020.108267 32533988!7832204!32533988     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetes+Res+Clin+Pract 2020 ; 165 (ä): 108267 Nephropedia Template TP {{tp|p=32533988|t=2020. COVID19 in South Asians/Asian Indians: Heterogeneity of data and implications for pathophysiology and research |pdf=|usr=}}{{32533988}} gab.com Text COVID19 in South Asians/Asian Indians: Heterogeneity of data and implications for pathophysiology and research JO: Diabetes Res Clin Pract http://www.kidney.de/pget.php?&tw=1&pmid=32533988 #FOAvip Despite a large population and limited health infrastructure, the incidence and mortality of Coronavirus Disease 2019 (COVID-19) has been lower in South Asia than many regions. The underlying reasons and mechanisms for this relative protection are not established. However both genetic and environmental factors might play a role. Polymorphisms in ACE2 gene, ACE gene and in genes for some of the host cell proteases could affect the viral entry and replication. There is some evidence that HLA polymorphisms and several pathways involved in immune and inflammatory response could contribute to ethnic variation. Cross immunity because of past exposure to viral infections as well as malaria is likely to protect from the severe manifestations of disease. Role of BCG vaccination in trained innate immunity is recognised and could be a protective factor against COVID-19. There is limited evidence of the possibility of a less virulent viral strain circulating in South Asia. There is evidence from different parts of the world that temperature and humidity can influence viral survival as well as the host immune response. Finally implementation of early containment measures by some South Asian countries has also contributed to a less disease burden. Twit Text FOAVip COVID19 in South Asians/Asian Indians: Heterogeneity of data and implications for pathophysiology and research ????Diabetes Res Clin Pract http://www.kidney.de/pget.php?&tw=1&pmid=32533988 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32533988 #FOAvip English Wikipedia <ref>{{Cite pmid|32533988}}</ref> COVID19 in South Asians/Asian Indians: Heterogeneity of data and implications for pathophysiology and research #MMPMID32533988 Gupta R; Misra A Diabetes Res Clin Pract 2020[Jul]; 165 (ä): 108267 PMID32533988show ga Despite a large population and limited health infrastructure, the incidence and mortality of Coronavirus Disease 2019 (COVID-19) has been lower in South Asia than many regions. The underlying reasons and mechanisms for this relative protection are not established. However both genetic and environmental factors might play a role. Polymorphisms in ACE2 gene, ACE gene and in genes for some of the host cell proteases could affect the viral entry and replication. There is some evidence that HLA polymorphisms and several pathways involved in immune and inflammatory response could contribute to ethnic variation. Cross immunity because of past exposure to viral infections as well as malaria is likely to protect from the severe manifestations of disease. Role of BCG vaccination in trained innate immunity is recognised and could be a protective factor against COVID-19. There is limited evidence of the possibility of a less virulent viral strain circulating in South Asia. There is evidence from different parts of the world that temperature and humidity can influence viral survival as well as the host immune response. Finally implementation of early containment measures by some South Asian countries has also contributed to a less disease burden. |ADAM17 Protein/genetics[MESH] |Alleles[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Asia/epidemiology[MESH] |Asian People[MESH] |BCG Vaccine[MESH] |Bangladesh/epidemiology/ethnology[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Coronavirus Infections/*epidemiology/*ethnology/genetics[MESH] |Ethnicity[MESH] |Global Health[MESH] |Humans[MESH] |Immune System[MESH] |Immunity, Innate[MESH] |Incidence[MESH] |India/epidemiology/ethnology[MESH] |Inflammation[MESH] |Mutation[MESH] |Nepal/epidemiology/ethnology[MESH] |Pakistan/epidemiology/ethnology[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/genetics[MESH] |Pneumonia, Viral/*epidemiology/*ethnology/genetics[MESH] |Polymorphism, Genetic[MESH] |Prevalence[MESH] |SARS-CoV-2[MESH]COVID19 in South Asians/Asian Indians: Heterogeneity of data and impli(epmc).pdf DeepDyve Pubget Overpricing