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10.1007/s10495-020-01614-4 http://scihub22266oqcxt.onion/10.1007/s10495-020-01614-4 32533513!7291609!32533513     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Apoptosis 2020 ; 25 (7-8): 474-480 Nephropedia Template TP {{tp|p=32533513|t=2020. Cytosolic DNA sensing through cGAS and STING is inactivated by gene mutations in pangolins |pdf=|usr=}}{{32533513}} gab.com Text Cytosolic DNA sensing through cGAS and STING is inactivated by gene mutations in pangolins JO: Apoptosis http://www.kidney.de/pget.php?&tw=1&pmid=32533513 #FOAvip The release of DNA into the cytoplasm upon damage to the nucleus or during viral infection triggers an interferon-mediated defense response, inflammation and cell death. In human cells cytoplasmic DNA is sensed by cyclic GMP-AMP Synthase (cGAS) and Absent In Melanoma 2 (AIM2). Here, we report the identification of a "natural knockout" model of cGAS. Comparative genomics of phylogenetically diverse mammalian species showed that cGAS and its interaction partner Stimulator of Interferon Genes (STING) have been inactivated by mutations in the Malayan pangolin whereas other mammals retained intact copies of these genes. The coding sequences of CGAS and STING1 are also disrupted by premature stop codons and frame-shift mutations in Chinese and tree pangolins, suggesting that expression of these genes was lost in a common ancestor of all pangolins that lived more than 20 million years ago. AIM2 is retained in a functional form in pangolins whereas it is inactivated by mutations in carnivorans, the phylogenetic sister group of pangolins. The deficiency of cGAS and STING points to the existence of alternative mechanisms of controlling cytoplasmic DNA-associated cell damage and viral infections in pangolins. Twit Text FOAVip Cytosolic DNA sensing through cGAS and STING is inactivated by gene mutations in pangolins ????Apoptosis http://www.kidney.de/pget.php?&tw=1&pmid=32533513 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32533513 #FOAvip English Wikipedia <ref>{{Cite pmid|32533513}}</ref> Cytosolic DNA sensing through cGAS and STING is inactivated by gene mutations in pangolins #MMPMID32533513 Fischer H; Tschachler E; Eckhart L Apoptosis 2020[Aug]; 25 (7-8): 474-480 PMID32533513show ga The release of DNA into the cytoplasm upon damage to the nucleus or during viral infection triggers an interferon-mediated defense response, inflammation and cell death. In human cells cytoplasmic DNA is sensed by cyclic GMP-AMP Synthase (cGAS) and Absent In Melanoma 2 (AIM2). Here, we report the identification of a "natural knockout" model of cGAS. Comparative genomics of phylogenetically diverse mammalian species showed that cGAS and its interaction partner Stimulator of Interferon Genes (STING) have been inactivated by mutations in the Malayan pangolin whereas other mammals retained intact copies of these genes. The coding sequences of CGAS and STING1 are also disrupted by premature stop codons and frame-shift mutations in Chinese and tree pangolins, suggesting that expression of these genes was lost in a common ancestor of all pangolins that lived more than 20 million years ago. AIM2 is retained in a functional form in pangolins whereas it is inactivated by mutations in carnivorans, the phylogenetic sister group of pangolins. The deficiency of cGAS and STING points to the existence of alternative mechanisms of controlling cytoplasmic DNA-associated cell damage and viral infections in pangolins. |Animals[MESH] |Base Sequence[MESH] |Cats[MESH] |China[MESH] |Codon, Terminator[MESH] |Cytosol/immunology/metabolism[MESH] |DNA-Binding Proteins/*genetics/immunology[MESH] |DNA/*genetics/immunology[MESH] |Gene Expression Regulation[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Interferon Regulatory Factors/deficiency/*genetics/immunology[MESH] |Malaysia[MESH] |Membrane Proteins/deficiency/*genetics/immunology[MESH] |Mutation[MESH] |Nucleotidyltransferases/deficiency/*genetics/immunology[MESH] |Pangolins/*genetics/immunology[MESH] |Phylogeny[MESH]Cytosolic DNA sensing through cGAS and STING is inactivated by gene mu(epmc).pdf DeepDyve Pubget Overpricing