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10.1016/j.medcli.2020.04.018

http://scihub22266oqcxt.onion/10.1016/j.medcli.2020.04.018
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suck abstract from ncbi


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pmid32532461      Med+Clin+(Barc) 2020 ; 155 (4): 159-161
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  • Eficacia de los pulsos de corticoides en pacientes con sindrome de liberacion de citocinas inducido por infeccion por SARS-CoV-2 #MMPMID32532461
  • Callejas Rubio JL; Luna Del Castillo JD; de la Hera Fernandez J; Guirao Arrabal E; Colmenero Ruiz M; Ortego Centeno N
  • Med Clin (Barc) 2020[Aug]; 155 (4): 159-161 PMID32532461show ga
  • INTRODUCTION: Cytokine storm syndrome (CSS) is a serious complication of COVID-19 patients. Treatment is tocilizumab. The use of glucocorticoids (GC) is controversial. In other very similar CSS, such as macrophage activation syndrome (MAS) and hemophagocytic syndrome (HFS), the main treatment are corticosteroids. Our objective is to evaluate the efficacy of GC in the CSS by COVID-19. PATIENTS: We included 92 patients with CSS associated to COVID-19 who received GC, GC, and tocilizumab and only tocilizumab. We determine CSS markers. We evaluated mortality, intubation, and a combined variable. RESULTS: In all cases the percentages of events were lower in the group of patients with GC was administered. The hazard ratio of the final variables with GC versus the group in which only tocilizumab was administered was lower as CGs were considered, with statistical significance for survival. DISCUSSION: The early use of GC pulses could control SLC, with a lower requirement to use tocilizumab and a decrease in events such as intubation and death.
  • |*Betacoronavirus[MESH]
  • |Adrenal Cortex Hormones/*administration & dosage[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Antibodies, Monoclonal, Humanized/*administration & dosage[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*complications/immunology/mortality[MESH]
  • |Cytokine Release Syndrome/*drug therapy/etiology/mortality[MESH]
  • |Drug Administration Schedule[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Intubation, Intratracheal/statistics & numerical data[MESH]
  • |Kaplan-Meier Estimate[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/immunology/mortality[MESH]
  • |Retrospective Studies[MESH]


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