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10.1016/j.jns.2020.116936 http://scihub22266oqcxt.onion/10.1016/j.jns.2020.116936 32532449!7241348!32532449     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neurol+Sci 2020 ; 415 (ä): 116936 Nephropedia Template TP {{tp|p=32532449|t=2020. Part I SARS-CoV-2 triggered PANIC attack in severe COVID-19 |pdf=|usr=}}{{32532449}} gab.com Text Part I SARS-CoV-2 triggered PANIC attack in severe COVID-19 JO: J Neurol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32532449 #FOAvip The coronavirus disease 2019 (COVID-19) pandemic has produced a world-wide collapse of social and economic infrastructure, as well as constrained our freedom of movement. This respiratory tract infection is nefarious in how it targets the most distal and highly vulnerable aspect of the human bronchopulmonary tree, specifically, the delicate yet irreplaceable alveoli that are responsible for the loading of oxygen upon red cell hemoglobin for use by all of the body's tissues. In most symptomatic individuals, the disease is a mild immune-mediated syndrome, with limited damage to the lung tissues. About 20% of those affected experience a disease course characterized by a cataclysmic set of immune activation responses that can culminate in the diffuse and irreversible obliteration of the distal alveoli, leading to a virtual collapse of the gas-exchange apparatus. Here, in Part I of a duology on the characterization and potential treatment for COVID-19, we define severe COVID-19 as a consequence of the ability of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to trigger what we now designate for the first time as a 'Prolific Activation of a Network-Immune-Inflammatory Crisis', or 'PANIC' Attack, in the alveolar tree. In Part II we describe an immunotherapeutic hypothesis worthy of the organization of a randomized clinical trial in order to ascertain whether a repurposed, generic, inexpensive, and widely available agent is capable of abolishing 'PANIC'; thereby preventing or mitigating severe COVID-19, with monumental ramifications for world health, and the global pandemic that continues to threaten it. Twit Text FOAVip Part I SARS-CoV-2 triggered PANIC attack in severe COVID-19 ????J Neurol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32532449 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32532449 #FOAvip English Wikipedia <ref>{{Cite pmid|32532449}}</ref> Part I SARS-CoV-2 triggered PANIC attack in severe COVID-19 #MMPMID32532449 Frohman EM; Villemarette-Pittman NR; Melamed E; Cruz RA; Longmuir R; Varkey TC; Steinman L; Zamvil SS; Frohman TC J Neurol Sci 2020[Aug]; 415 (ä): 116936 PMID32532449show ga The coronavirus disease 2019 (COVID-19) pandemic has produced a world-wide collapse of social and economic infrastructure, as well as constrained our freedom of movement. This respiratory tract infection is nefarious in how it targets the most distal and highly vulnerable aspect of the human bronchopulmonary tree, specifically, the delicate yet irreplaceable alveoli that are responsible for the loading of oxygen upon red cell hemoglobin for use by all of the body's tissues. In most symptomatic individuals, the disease is a mild immune-mediated syndrome, with limited damage to the lung tissues. About 20% of those affected experience a disease course characterized by a cataclysmic set of immune activation responses that can culminate in the diffuse and irreversible obliteration of the distal alveoli, leading to a virtual collapse of the gas-exchange apparatus. Here, in Part I of a duology on the characterization and potential treatment for COVID-19, we define severe COVID-19 as a consequence of the ability of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to trigger what we now designate for the first time as a 'Prolific Activation of a Network-Immune-Inflammatory Crisis', or 'PANIC' Attack, in the alveolar tree. In Part II we describe an immunotherapeutic hypothesis worthy of the organization of a randomized clinical trial in order to ascertain whether a repurposed, generic, inexpensive, and widely available agent is capable of abolishing 'PANIC'; thereby preventing or mitigating severe COVID-19, with monumental ramifications for world health, and the global pandemic that continues to threaten it. |*Models, Immunological[MESH] |Betacoronavirus/*immunology/physiology[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology/physiopathology[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/physiopathology[MESH]Part I SARS-CoV-2 triggered PANIC attack in severe COVID-19 (epmc).pdf DeepDyve Pubget Overpricing