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10.1016/j.msard.2020.102250

http://scihub22266oqcxt.onion/10.1016/j.msard.2020.102250
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suck abstract from ncbi


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pmid32531754      Mult+Scler+Relat+Disord 2020 ; 44 (ä): 102250
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  • Covid-19 in a patient with multiple sclerosis treated with natalizumab: May the blockade of integrins have a protective role? #MMPMID32531754
  • Aguirre C; Meca-Lallana V; Barrios-Blandino A; Del Rio B; Vivancos J
  • Mult Scler Relat Disord 2020[Sep]; 44 (ä): 102250 PMID32531754show ga
  • The disease caused by the new coronavirus SARS-CoV-2 (COVID-19) is currently spread worldwide . Recent data supports SARS-CoV-2 may use integrins to enter human cells. Therefore, anti-integrins therapies might be an alternative against the infection . Natalizumab, approved for Multiple Sclerosis (MS) treatment, acts blocking alpha4-integrin. We report a MS patient treated with natalizumab who develops COVID-19, with excellent recovery and repeated negative results in 5 consecutive microbiological studies. We postulate this may be due to the blockade of integrins induced by natalizumab.
  • |Adolescent[MESH]
  • |COVID-19/complications/*prevention & control[MESH]
  • |Humans[MESH]
  • |Immunologic Factors/*therapeutic use[MESH]
  • |Integrin alpha4/antagonists & inhibitors[MESH]
  • |Male[MESH]
  • |Multiple Sclerosis/complications/*drug therapy[MESH]
  • |Natalizumab/*therapeutic use[MESH]


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