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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Mult+Scler+Relat+Disord 2020 ; 44 (ä): 102250 Nephropedia Template TP
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Covid-19 in a patient with multiple sclerosis treated with natalizumab: May the blockade of integrins have a protective role? #MMPMID32531754
Aguirre C; Meca-Lallana V; Barrios-Blandino A; Del Rio B; Vivancos J
Mult Scler Relat Disord 2020[Sep]; 44 (ä): 102250 PMID32531754show ga
The disease caused by the new coronavirus SARS-CoV-2 (COVID-19) is currently spread worldwide . Recent data supports SARS-CoV-2 may use integrins to enter human cells. Therefore, anti-integrins therapies might be an alternative against the infection . Natalizumab, approved for Multiple Sclerosis (MS) treatment, acts blocking alpha4-integrin. We report a MS patient treated with natalizumab who develops COVID-19, with excellent recovery and repeated negative results in 5 consecutive microbiological studies. We postulate this may be due to the blockade of integrins induced by natalizumab.