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10.1016/j.cmi.2020.05.036

http://scihub22266oqcxt.onion/10.1016/j.cmi.2020.05.036
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suck abstract from ncbi


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pmid32531475      Clin+Microbiol+Infect 2020 ; 26 (9): 1256.e9-1256.e11
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  • Clinical evaluation of serological IgG antibody response on the Abbott Architect for established SARS-CoV-2 infection #MMPMID32531475
  • Chew KL; Tan SS; Saw S; Pajarillaga A; Zaine S; Khoo C; Wang W; Tambyah P; Jureen R; Sethi SK
  • Clin Microbiol Infect 2020[Sep]; 26 (9): 1256.e9-1256.e11 PMID32531475show ga
  • OBJECTIVE: This study aimed to evaluate the diagnostic performance of the Abbott Architect SARS-CoV-2 IgG assay in COVID-19 patients. METHODS: Residual sera from 177 symptomatic SARS-CoV-2-positive patients and 163 non-COVID-19 patients were tested for antibody with the Abbott SARS-CoV-2 IgG assay (Abbott Diagnostics, Chicago, USA). Clinical records for COVID-19 patients were reviewed to determine the time from onset of clinical illness to testing. RESULTS: Specificity of the assay was 100.0% (95%CI: 97.1-100.0%). The clinical sensitivity of the assay varied depending on time from onset of symptoms, increasing with longer periods from the onset of clinical illness. The clinical sensitivity at /=21 days 84.4% (27/32; 95%CI: 66.5-94.1%). Clinical sensitivity was higher in the >/=14-day group compared to <14 days. There were no differences between the 14-20-day and >/=21-days groups; the combined clinical sensitivity for these groups (>/=14 days) was 84.2% (49/57; 71.6-92.1%). CONCLUSION: The Abbott SARS-CoV-2 IgG test has high specificity. Clinical sensitivity was limited in the early stages of disease but improved from 14 days after the onset of clinical symptoms.
  • |Antibodies, Viral/*blood[MESH]
  • |Antibody Formation[MESH]
  • |COVID-19 Serological Testing/*methods[MESH]
  • |COVID-19/*diagnosis[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/*blood[MESH]
  • |Sensitivity and Specificity[MESH]
  • |Singapore[MESH]


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