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10.1016/j.cca.2020.06.012 http://scihub22266oqcxt.onion/10.1016/j.cca.2020.06.012 32531257!7282743!32531257     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Chim+Acta 2020 ; 509 (ä): 135-138 Nephropedia Template TP {{tp|p=32531257|t=2020. Lactate dehydrogenase and C-reactive protein as predictors of respiratory failure in CoVID-19 patients |pdf=|usr=}}{{32531257}} gab.com Text Lactate dehydrogenase and C-reactive protein as predictors of respiratory failure in CoVID-19 patients JO: Clin Chim Acta http://www.kidney.de/pget.php?&tw=1&pmid=32531257 #FOAvip OBJECTIVE: The dramatic worldwide CoVID-19 infection requires the identification of a reliable and inexpensive tool to quickly discriminate patients with a more unfavorable outcome. METHODS: We performed routine laboratory tests suitable to identify tissue damage and inflammatory status in 123 consecutive CoVID-19 patients admitted to the Emergency Department of the hospital of Piacenza (Emilia-Romagna, Northern Italy). The results were correlated with patients' respiratory function evaluated by the partial pressure of arterial oxygen to fraction of inspired oxygen ratio (PaO2/FiO2). RESULTS: The most common laboratory abnormalities were lymphocytopenia and elevated values of C-reactive protein (CRP) and lactate dehydrogenase (LDH). Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatine kinase (CK) were also increased. The respiratory performance (PaO2/FiO2) showed a strong inverse correlation with LDH (r = 0.62, r(2) 0.38, p value < 0.0001) and CRP (r = 0.55, r(2) 0.31, p value < 0.0001). PaO2/FiO2 values also showed a significant inverse correlation with age (r = -0.37, p < 0.0001), AST (r = -0.31, p < 0.01), WBC (r = -0.49, p < 0.0001), neutrophils count (r = -0.5, p < 0.001). ROC curves showed a sensitivity of 75% and specificity of 70% for the LDH cut-off value of 450 U/L and a sensitivity of 72% and specificity of 71% for the CRP cut-off value of 11 mg/dl in identifying CoVID-19 with moderate-severe ARDS. CONCLUSIONS: LDH and CRP may be related to respiratory function (PaO2/FiO2) and be a predictor of respiratory failure in CoVID-19 patients. LDH and CRP should be considered a useful test for the early identification of patients who require closer respiratory monitoring and more aggressive supportive therapies to avoid poor prognosis. Twit Text FOAVip Lactate dehydrogenase and C-reactive protein as predictors of respiratory failure in CoVID-19 patients ????Clin Chim Acta http://www.kidney.de/pget.php?&tw=1&pmid=32531257 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32531257 #FOAvip English Wikipedia <ref>{{Cite pmid|32531257}}</ref> Lactate dehydrogenase and C-reactive protein as predictors of respiratory failure in CoVID-19 patients #MMPMID32531257 Poggiali E; Zaino D; Immovilli P; Rovero L; Losi G; Dacrema A; Nuccetelli M; Vadacca GB; Guidetti D; Vercelli A; Magnacavallo A; Bernardini S; Terracciano C Clin Chim Acta 2020[Oct]; 509 (ä): 135-138 PMID32531257show ga OBJECTIVE: The dramatic worldwide CoVID-19 infection requires the identification of a reliable and inexpensive tool to quickly discriminate patients with a more unfavorable outcome. METHODS: We performed routine laboratory tests suitable to identify tissue damage and inflammatory status in 123 consecutive CoVID-19 patients admitted to the Emergency Department of the hospital of Piacenza (Emilia-Romagna, Northern Italy). The results were correlated with patients' respiratory function evaluated by the partial pressure of arterial oxygen to fraction of inspired oxygen ratio (PaO2/FiO2). RESULTS: The most common laboratory abnormalities were lymphocytopenia and elevated values of C-reactive protein (CRP) and lactate dehydrogenase (LDH). Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatine kinase (CK) were also increased. The respiratory performance (PaO2/FiO2) showed a strong inverse correlation with LDH (r = 0.62, r(2) 0.38, p value < 0.0001) and CRP (r = 0.55, r(2) 0.31, p value < 0.0001). PaO2/FiO2 values also showed a significant inverse correlation with age (r = -0.37, p < 0.0001), AST (r = -0.31, p < 0.01), WBC (r = -0.49, p < 0.0001), neutrophils count (r = -0.5, p < 0.001). ROC curves showed a sensitivity of 75% and specificity of 70% for the LDH cut-off value of 450 U/L and a sensitivity of 72% and specificity of 71% for the CRP cut-off value of 11 mg/dl in identifying CoVID-19 with moderate-severe ARDS. CONCLUSIONS: LDH and CRP may be related to respiratory function (PaO2/FiO2) and be a predictor of respiratory failure in CoVID-19 patients. LDH and CRP should be considered a useful test for the early identification of patients who require closer respiratory monitoring and more aggressive supportive therapies to avoid poor prognosis. |*Betacoronavirus[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Biomarkers/blood[MESH] |C-Reactive Protein/*metabolism[MESH] |COVID-19[MESH] |Clinical Laboratory Techniques/methods/trends[MESH] |Coronavirus Infections/*blood/diagnosis/epidemiology[MESH] |Female[MESH] |Humans[MESH] |Italy/epidemiology[MESH] |L-Lactate Dehydrogenase/*blood[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Patient Admission/trends[MESH] |Pneumonia, Viral/*blood/diagnosis/epidemiology[MESH] |Predictive Value of Tests[MESH] |Respiratory Insufficiency/*blood/diagnosis/epidemiology[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH]Lactate dehydrogenase and C-reactive protein as predictors of respirat(epmc).pdf DeepDyve Pubget Overpricing