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10.1111/bjh.16938

http://scihub22266oqcxt.onion/10.1111/bjh.16938
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32531085!7323335!32531085
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suck abstract from ncbi


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pmid32531085      Br+J+Haematol 2020 ; 190 (4): 520-524
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  • C1 esterase inhibitor and the contact system in COVID-19 #MMPMID32531085
  • Thomson TM; Toscano-Guerra E; Casis E; Paciucci R
  • Br J Haematol 2020[Aug]; 190 (4): 520-524 PMID32531085show ga
  • Coronavirus disease 2019 (COVID-19) is frequently associated with severe systemic consequences, including vasculitis, a hyperinflammatory state and hypercoagulation. The mechanisms leading to these life-threatening abnormalities are multifactorial. Based on the analysis of publicly available interactomes, we propose that severe acute respiratory syndrome coronavirus-2 infection directly causes a deficiency in C1 esterase inhibitor, a pathogen-specific mechanism that may help explain significant systemic abnormalities in patients with COVID-19.
  • |COVID-19/*metabolism/pathology[MESH]
  • |Complement C1 Inhibitor Protein/*metabolism[MESH]
  • |Humans[MESH]


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