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C1 esterase inhibitor and the contact system in COVID-19 #MMPMID32531085
Thomson TM; Toscano-Guerra E; Casis E; Paciucci R
Br J Haematol 2020[Aug]; 190 (4): 520-524 PMID32531085show ga
Coronavirus disease 2019 (COVID-19) is frequently associated with severe systemic consequences, including vasculitis, a hyperinflammatory state and hypercoagulation. The mechanisms leading to these life-threatening abnormalities are multifactorial. Based on the analysis of publicly available interactomes, we propose that severe acute respiratory syndrome coronavirus-2 infection directly causes a deficiency in C1 esterase inhibitor, a pathogen-specific mechanism that may help explain significant systemic abnormalities in patients with COVID-19.