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10.15403/jgld-2513

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32530989!ä!32530989

suck abstract from ncbi


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pmid32530989      J+Gastrointestin+Liver+Dis 2020 ; 29 (2): 219-226
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  • Abnormal Liver Function Tests of Patients with Coronavirus Disease 2019 in Mainland China: A Systematic Review and Meta- Analysis #MMPMID32530989
  • Xin S; Xu J; Yu Y
  • J Gastrointestin Liver Dis 2020[Jun]; 29 (2): 219-226 PMID32530989show ga
  • AIMS: Comparing the risk of abnormal liver function tests between severe and non-severe patients with coronavirus disease 2019 (COVID-19) by meta-analysis. METHODS: A literature search was conducted using the databases PubMed, Embase, and Cochrane Library. Odds ratios (ORs) and 95% confidence intervals (CIs) were pooled using fixed- or random-effects models. Publication bias was detected by the Harbord test. RESULTS: We included 8 articles comprising 7,467 COVID-19 patients. When compared between severe and non-severe COVID-19 patients, the pooled ORs of elevated alanine aminotransferase, aspartate aminotransferase, total bilirubin, and lactate dehydrogenase levels were 2.35 (95% CI 1.38-3.98), 3.21 (95% CI 2.59-3.98), 1.87 (95% CI 1.32-2.65), and 4.83 (95% CI 2.90-8.05), respectively. CONCLUSIONS: The severity of COVID-19 is associated with liver damage, and can be a risk factor for abnormal liver function tests.
  • |*Betacoronavirus[MESH]
  • |*Severity of Illness Index[MESH]
  • |COVID-19[MESH]
  • |China[MESH]
  • |Coronavirus Infections/diagnosis/*physiopathology[MESH]
  • |Hepatic Insufficiency/diagnosis/*virology[MESH]
  • |Humans[MESH]
  • |Liver Function Tests[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/diagnosis/*physiopathology[MESH]


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