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10.1021/acs.jcim.0c00501 http://scihub22266oqcxt.onion/10.1021/acs.jcim.0c00501 32530284!7318555!32530284     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Chem+Inf+Model 2020 ; 60 (12): 5853-5865 Nephropedia Template TP {{tp|p=32530284|t=2020. Decoding SARS-CoV-2 Transmission and Evolution and Ramifications for COVID-19 Diagnosis, Vaccine, and Medicine |pdf=|usr=}}{{32530284}} gab.com Text Decoding SARS-CoV-2 Transmission and Evolution and Ramifications for COVID-19 Diagnosis, Vaccine, and Medicine JO: J Chem Inf Model http://www.kidney.de/pget.php?&tw=1&pmid=32530284 #FOAvip Tremendous effort has been given to the development of diagnostic tests, preventive vaccines, and therapeutic medicines for coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Much of this development has been based on the reference genome collected on January 5, 2020. Based on the genotyping of 15?140 genome samples collected up to June 1, 2020, we report that SARS-CoV-2 has undergone 8309 single mutations which can be clustered into six subtypes. We introduce mutation ratio and mutation h-index to characterize the protein conservativeness and unveil that SARS-CoV-2 envelope protein, main protease, and endoribonuclease protein are relatively conservative, while SARS-CoV-2 nucleocapsid protein, spike protein, and papain-like protease are relatively nonconservative. In particular, we have identified mutations on 40% of nucleotides in the nucleocapsid gene in the population level, signaling potential impacts on the ongoing development of COVID-19 diagnosis, vaccines, and antibody and small-molecular drugs. Twit Text FOAVip Decoding SARS-CoV-2 Transmission and Evolution and Ramifications for COVID-19 Diagnosis, Vaccine, and Medicine ????J Chem Inf Model http://www.kidney.de/pget.php?&tw=1&pmid=32530284 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32530284 #FOAvip English Wikipedia <ref>{{Cite pmid|32530284}}</ref> Decoding SARS-CoV-2 Transmission and Evolution and Ramifications for COVID-19 Diagnosis, Vaccine, and Medicine #MMPMID32530284 Wang R; Hozumi Y; Yin C; Wei GW J Chem Inf Model 2020[Dec]; 60 (12): 5853-5865 PMID32530284show ga Tremendous effort has been given to the development of diagnostic tests, preventive vaccines, and therapeutic medicines for coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Much of this development has been based on the reference genome collected on January 5, 2020. Based on the genotyping of 15?140 genome samples collected up to June 1, 2020, we report that SARS-CoV-2 has undergone 8309 single mutations which can be clustered into six subtypes. We introduce mutation ratio and mutation h-index to characterize the protein conservativeness and unveil that SARS-CoV-2 envelope protein, main protease, and endoribonuclease protein are relatively conservative, while SARS-CoV-2 nucleocapsid protein, spike protein, and papain-like protease are relatively nonconservative. In particular, we have identified mutations on 40% of nucleotides in the nucleocapsid gene in the population level, signaling potential impacts on the ongoing development of COVID-19 diagnosis, vaccines, and antibody and small-molecular drugs. |*COVID-19/diagnosis/epidemiology/prevention & control/therapy[MESH] |Antibodies, Viral/metabolism[MESH] |Coronavirus 3C Proteases/chemistry/genetics[MESH] |Coronavirus Envelope Proteins/chemistry/genetics[MESH] |Coronavirus Nucleocapsid Proteins/chemistry/genetics[MESH] |Coronavirus Papain-Like Proteases/chemistry/genetics[MESH] |Endoribonucleases/chemistry/genetics[MESH] |Genome, Viral[MESH] |Genotype[MESH] |Geography[MESH] |Humans[MESH] |Mutant Proteins/chemistry/genetics[MESH] |Mutation[MESH] |Phosphoproteins/chemistry/genetics[MESH] |Protein Conformation[MESH] |SARS-CoV-2/*classification/*metabolism[MESH] |Spike Glycoprotein, Coronavirus/chemistry/genetics[MESH] |Vaccines/metabolism[MESH]Decoding SARS-CoV-2 Transmission and Evolution and Ramifications for C(epmc).pdf DeepDyve Pubget Overpricing