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10.1002/hed.26317

http://scihub22266oqcxt.onion/10.1002/hed.26317
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32530131!7307014!32530131
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suck abstract from ncbi


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pmid32530131      Head+Neck 2020 ; 42 (7): 1621-1628
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  • False-positive reverse transcriptase polymerase chain reaction screening for SARS-CoV-2 in the setting of urgent head and neck surgery and otolaryngologic emergencies during the pandemic: Clinical implications #MMPMID32530131
  • Katz AP; Civantos FJ; Sargi Z; Leibowitz JM; Nicolli EA; Weed D; Moskovitz AE; Civantos AM; Andrews DM; Martinez O; Thomas GR
  • Head Neck 2020[Jul]; 42 (7): 1621-1628 PMID32530131show ga
  • BACKGROUND: No reports describe falsepositive reverse transcriptase polymerase chain reaction (RT-PCR) for novel coronavirus in preoperative screening. METHODS: Preoperative patients had one or two nasopharyngeal swabs, depending on low or high risk of viral transmission. Positive tests were repeated. RESULTS: Forty-three of 52 patients required two or more preoperative tests. Four (9.3%) had discrepant results (positive/negative). One of these left the coronavirus disease (COVID) unit against medical advice despite an orbital abscess, with unknown true disease status. The remaining 3 of 42 (7.1%) had negative repeat RT-PCR. Although ultimately considered falsepositives, one was sent to a COVID unit postoperatively and two had urgent surgery delayed. Assuming negative repeat RT-PCR, clear chest imaging, and lack of subsequent symptoms represent the "gold standard," RT-PCR specificity was 0.97. CONCLUSIONS: If false positives are suspected, we recommend computed tomography (CT) of the chest and repeat RT-PCR. Validated serum immunoglobulin testing may ultimately prove useful.
  • |*False Positive Reactions[MESH]
  • |*Otorhinolaryngologic Surgical Procedures[MESH]
  • |*Reverse Transcriptase Polymerase Chain Reaction[MESH]
  • |Aged, 80 and over[MESH]
  • |Betacoronavirus/*genetics[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*diagnosis/epidemiology[MESH]
  • |Emergencies[MESH]
  • |Female[MESH]
  • |Florida/epidemiology[MESH]
  • |Humans[MESH]
  • |Lung/diagnostic imaging[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nasopharynx/virology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnosis/epidemiology[MESH]
  • |Preoperative Care[MESH]
  • |RNA, Viral[MESH]
  • |SARS-CoV-2[MESH]
  • |Tomography, X-Ray Computed[MESH]


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