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10.1002/ehf2.12805 http://scihub22266oqcxt.onion/10.1002/ehf2.12805 32529795!7307078!32529795     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32529795.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ESC+Heart+Fail 2020 ; 7 (5): 2440-2447 Nephropedia Template TP {{tp|p=32529795|t=2020. Detection of viral SARS-CoV-2 genomes and histopathological changes in endomyocardial biopsies |pdf=|usr=}}{{32529795}} gab.com Text Detection of viral SARS-CoV-2 genomes and histopathological changes in endomyocardial biopsies JO: ESC Heart Fail http://www.kidney.de/pget.php?&tw=1&pmid=32529795 #FOAvip AIMS: Since December 2019, the novel coronavirus SARS-CoV-2 has spread rapidly throughout China and keeps the world in suspense. Cardiovascular complications with myocarditis and embolism due to COVID-19 have been reported. SARS-CoV-2 genome detection in the heart muscle has not been demonstrated so far, and the underlying pathophysiological mechanisms remain to be investigated. METHODS AND RESULTS: Endomyocardial biopsies (EMBs) of 104 patients (mean age: 57.90 +/- 16.37 years; left ventricular ejection fraction: 33.7 +/- 14.6%, sex: n = 79 male/25 female) with suspected myocarditis or unexplained heart failure were analysed. EMB analysis included histology, immunohistochemistry, and detection of SARS-CoV-2 genomes by real-time reverse transcription polymerase chain reaction in the IKDT Berlin, Germany. Among 104 EMBs investigated, five were confirmed with SARS-CoV-2 infected by reverse real-time transcriptase polymerase chain reaction. We describe patients of different history of symptoms and time duration. Additionally, we investigated histopathological changes in myocardial tissue showing that the inflammatory process in EMBs seemed to permeate vascular wall leading to small arterial obliteration and damage. CONCLUSIONS: This is the first report that established the evidence of SARS-CoV-2 genomes detection in EMBs. In these patients, myocardial injury ischaemia may play a role, which could explain the ubiquitous troponin increases. EMB-based identification of the cause of myocardial injury may contribute to explain the different evolution of complicated SARS-CoV-2-infection and to design future specific and personalized treatment strategies. Twit Text FOAVip Detection of viral SARS-CoV-2 genomes and histopathological changes in endomyocardial biopsies ????ESC Heart Fail http://www.kidney.de/pget.php?&tw=1&pmid=32529795 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32529795 #FOAvip English Wikipedia <ref>{{Cite pmid|32529795}}</ref> Detection of viral SARS-CoV-2 genomes and histopathological changes in endomyocardial biopsies #MMPMID32529795 Escher F; Pietsch H; Aleshcheva G; Bock T; Baumeier C; Elsaesser A; Wenzel P; Hamm C; Westenfeld R; Schultheiss M; Gross U; Morawietz L; Schultheiss HP ESC Heart Fail 2020[Oct]; 7 (5): 2440-2447 PMID32529795show ga AIMS: Since December 2019, the novel coronavirus SARS-CoV-2 has spread rapidly throughout China and keeps the world in suspense. Cardiovascular complications with myocarditis and embolism due to COVID-19 have been reported. SARS-CoV-2 genome detection in the heart muscle has not been demonstrated so far, and the underlying pathophysiological mechanisms remain to be investigated. METHODS AND RESULTS: Endomyocardial biopsies (EMBs) of 104 patients (mean age: 57.90 +/- 16.37 years; left ventricular ejection fraction: 33.7 +/- 14.6%, sex: n = 79 male/25 female) with suspected myocarditis or unexplained heart failure were analysed. EMB analysis included histology, immunohistochemistry, and detection of SARS-CoV-2 genomes by real-time reverse transcription polymerase chain reaction in the IKDT Berlin, Germany. Among 104 EMBs investigated, five were confirmed with SARS-CoV-2 infected by reverse real-time transcriptase polymerase chain reaction. We describe patients of different history of symptoms and time duration. Additionally, we investigated histopathological changes in myocardial tissue showing that the inflammatory process in EMBs seemed to permeate vascular wall leading to small arterial obliteration and damage. CONCLUSIONS: This is the first report that established the evidence of SARS-CoV-2 genomes detection in EMBs. In these patients, myocardial injury ischaemia may play a role, which could explain the ubiquitous troponin increases. EMB-based identification of the cause of myocardial injury may contribute to explain the different evolution of complicated SARS-CoV-2-infection and to design future specific and personalized treatment strategies. |*Gene Expression Regulation[MESH] |Adult[MESH] |Age Factors[MESH] |Aged[MESH] |Biopsy, Needle[MESH] |COVID-19[MESH] |Cohort Studies[MESH] |Communicable Diseases, Emerging/epidemiology[MESH] |Coronavirus Infections/*epidemiology[MESH] |Disease Outbreaks/statistics & numerical data[MESH] |Endocardium/pathology[MESH] |Female[MESH] |Genomics[MESH] |Germany/epidemiology[MESH] |Heart Failure/genetics/*virology[MESH] |Humans[MESH] |Immunohistochemistry[MESH] |Incidence[MESH] |Male[MESH] |Middle Aged[MESH] |Myocarditis/genetics/*pathology/virology[MESH] |Pandemics/statistics & numerical data[MESH] |Pneumonia, Viral/*epidemiology[MESH] |Real-Time Polymerase Chain Reaction/methods[MESH] |Retrospective Studies[MESH] |Severe acute respiratory syndrome-related coronavirus/*genetics[MESH] |Sex Factors[MESH]Detection of viral SARS-CoV-2 genomes and histopathological changes in(epmc).pdf DeepDyve Pubget Overpricing