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10.1002/pd.5765 http://scihub22266oqcxt.onion/10.1002/pd.5765 32529643!7307070!32529643     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Prenat+Diagn 2020 ; 40 (13): 1655-1670 Nephropedia Template TP {{tp|p=32529643|t=2020. Mechanisms and evidence of vertical transmission of infections in pregnancy including SARS-CoV-2s |pdf=|usr=}}{{32529643}} gab.com Text Mechanisms and evidence of vertical transmission of infections in pregnancy including SARS-CoV-2s JO: Prenat Diagn http://www.kidney.de/pget.php?&tw=1&pmid=32529643 #FOAvip There remain unanswered questions concerning mother-to-child-transmission of SARS-CoV-2. Despite reports of neonatal COVID-19, SARS-CoV-2 has not been consistently isolated in perinatal samples, thus definitive proof of transplacental infection is still lacking. To address these questions, we assessed investigative tools used to confirm maternal-fetal infection and known protective mechanisms of the placental barrier that prevent transplacental pathogen migration. Forty studies of COVID-19 pregnancies reviewed suggest a lack of consensus on diagnostic strategy for congenital infection. Although real-time polymerase chain reaction of neonatal swabs was universally performed, a wide range of clinical samples was screened including vaginal secretions (22.5%), amniotic fluid (35%), breast milk (22.5%) and umbilical cord blood. Neonatal COVID-19 was reported in eight studies, two of which were based on the detection of SARS-CoV-2 IgM in neonatal blood. Histological examination demonstrated sparse viral particles, vascular malperfusion and inflammation in the placenta from pregnant women with COVID-19. The paucity of placental co-expression of ACE-2 and TMPRSS2, two receptors involved in cytoplasmic entry of SARS-CoV-2, may explain its relative insensitivity to transplacental infection. Viral interactions may utilise membrane receptors other than ACE-2 thus, tissue susceptibility may be broader than currently known. Further spatial-temporal studies are needed to determine the true potential for transplacental migration. Twit Text FOAVip Mechanisms and evidence of vertical transmission of infections in pregnancy including SARS-CoV-2s ????Prenat Diagn http://www.kidney.de/pget.php?&tw=1&pmid=32529643 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32529643 #FOAvip English Wikipedia <ref>{{Cite pmid|32529643}}</ref> Mechanisms and evidence of vertical transmission of infections in pregnancy including SARS-CoV-2s #MMPMID32529643 Mahyuddin AP; Kanneganti A; Wong JJL; Dimri PS; Su LL; Biswas A; Illanes SE; Mattar CNZ; Huang RY; Choolani M Prenat Diagn 2020[Dec]; 40 (13): 1655-1670 PMID32529643show ga There remain unanswered questions concerning mother-to-child-transmission of SARS-CoV-2. Despite reports of neonatal COVID-19, SARS-CoV-2 has not been consistently isolated in perinatal samples, thus definitive proof of transplacental infection is still lacking. To address these questions, we assessed investigative tools used to confirm maternal-fetal infection and known protective mechanisms of the placental barrier that prevent transplacental pathogen migration. Forty studies of COVID-19 pregnancies reviewed suggest a lack of consensus on diagnostic strategy for congenital infection. Although real-time polymerase chain reaction of neonatal swabs was universally performed, a wide range of clinical samples was screened including vaginal secretions (22.5%), amniotic fluid (35%), breast milk (22.5%) and umbilical cord blood. Neonatal COVID-19 was reported in eight studies, two of which were based on the detection of SARS-CoV-2 IgM in neonatal blood. Histological examination demonstrated sparse viral particles, vascular malperfusion and inflammation in the placenta from pregnant women with COVID-19. The paucity of placental co-expression of ACE-2 and TMPRSS2, two receptors involved in cytoplasmic entry of SARS-CoV-2, may explain its relative insensitivity to transplacental infection. Viral interactions may utilise membrane receptors other than ACE-2 thus, tissue susceptibility may be broader than currently known. Further spatial-temporal studies are needed to determine the true potential for transplacental migration. |*Infectious Disease Transmission, Vertical[MESH] |*Pregnancy Complications, Infectious[MESH] |COVID-19/*transmission/virology[MESH] |Female[MESH] |Humans[MESH] |Maternal-Fetal Exchange/immunology[MESH] |Pregnancy[MESH]Mechanisms and evidence of vertical transmission of infections in preg(epmc).pdf DeepDyve Pubget Overpricing