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10.18632/aging.103335 http://scihub22266oqcxt.onion/10.18632/aging.103335 32527987!7346040!32527987     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Aging+(Albany+NY) 2020 ; 12 (11): 10022-10034 Nephropedia Template TP {{tp|p=32527987|t=2020. Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients |pdf=|usr=}}{{32527987}} gab.com Text Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients JO: Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=32527987 #FOAvip The novel severe acute respiratory syndrome coronavirus 2 is the causative agent of coronavirus disease 2019, a new human infectious disease. While fever, cough, and respiratory distress are typical first symptoms, a fraction of those affected present instead with neurological symptoms suggestive of central nervous system compromise. This review summarizes the potential contribution of coronavirus disease 2019 to hemorrhagic stroke in the elderly and proposes possible mechanisms. Reports show that the most affected patients have underlying chronic diseases such as hypertension and diabetes, which are two key risk factors for hemorrhagic stroke. Angiotensin-converting enzyme 2 is the main host cell surface receptor interacting with the severe acute respiratory syndrome coronavirus 2 spike glycoprotein to allow viral entry and infection. We speculate that ensuing downregulation of angiotensin-converting enzyme 2 expression may compound the risk conferred by pre-existing comorbidities and critically influence the pathogenesis of hemorrhagic stroke by elevating blood pressure and impairing cerebrovascular endothelial function. Additionally, both age- and/or disease-related immune dysfunction and enhanced catecholamine release secondary to anxiety and stress may also aggravate central nervous system symptoms of severe acute respiratory syndrome coronavirus 2 infection. Thus, assessment of systemic inflammatory biomarkers and tight control of hemodynamic parameters upon admission are crucial to minimize mortality and morbidity in coronavirus disease 2019 patients with central nervous system symptoms suggestive of incipient stroke. Twit Text FOAVip Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients ????Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=32527987 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32527987 #FOAvip English Wikipedia <ref>{{Cite pmid|32527987}}</ref> Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients #MMPMID32527987 Wang H; Tang X; Fan H; Luo Y; Song Y; Xu Y; Chen Y Aging (Albany NY) 2020[Jun]; 12 (11): 10022-10034 PMID32527987show ga The novel severe acute respiratory syndrome coronavirus 2 is the causative agent of coronavirus disease 2019, a new human infectious disease. While fever, cough, and respiratory distress are typical first symptoms, a fraction of those affected present instead with neurological symptoms suggestive of central nervous system compromise. This review summarizes the potential contribution of coronavirus disease 2019 to hemorrhagic stroke in the elderly and proposes possible mechanisms. Reports show that the most affected patients have underlying chronic diseases such as hypertension and diabetes, which are two key risk factors for hemorrhagic stroke. Angiotensin-converting enzyme 2 is the main host cell surface receptor interacting with the severe acute respiratory syndrome coronavirus 2 spike glycoprotein to allow viral entry and infection. We speculate that ensuing downregulation of angiotensin-converting enzyme 2 expression may compound the risk conferred by pre-existing comorbidities and critically influence the pathogenesis of hemorrhagic stroke by elevating blood pressure and impairing cerebrovascular endothelial function. Additionally, both age- and/or disease-related immune dysfunction and enhanced catecholamine release secondary to anxiety and stress may also aggravate central nervous system symptoms of severe acute respiratory syndrome coronavirus 2 infection. Thus, assessment of systemic inflammatory biomarkers and tight control of hemodynamic parameters upon admission are crucial to minimize mortality and morbidity in coronavirus disease 2019 patients with central nervous system symptoms suggestive of incipient stroke. |Aged[MESH] |Animals[MESH] |COVID-19[MESH] |Cerebral Hemorrhage/*virology[MESH] |Coronavirus Infections/*complications/immunology/virology[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications/immunology/virology[MESH] |Risk Factors[MESH]Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patient(epmc).pdf DeepDyve Pubget Overpricing