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10.1126/science.abc3545 http://scihub22266oqcxt.onion/10.1126/science.abc3545 32527925!7292499!32527925     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2020 ; 369 (6504): 706-712 Nephropedia Template TP {{tp|p=32527925|t=2020. Type III interferons disrupt the lung epithelial barrier upon viral recognition |pdf=|usr=}}{{32527925}} gab.com Text Type III interferons disrupt the lung epithelial barrier upon viral recognition JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=32527925 #FOAvip Viral infections of the lower respiratory tract are a leading cause of mortality. Mounting evidence indicates that most severe cases are characterized by aberrant immune responses and do not depend on viral burden. In this study, we assessed how type III interferons (IFN-lambda) contribute to the pathogenesis induced by RNA viruses. We report that IFN-lambda is present in the lower, but not upper, airways of patients with coronavirus disease 2019 (COVID-19). In mice, we demonstrate that IFN-lambda produced by lung dendritic cells in response to a synthetic viral RNA induces barrier damage, causing susceptibility to lethal bacterial superinfections. These findings provide a strong rationale for rethinking the pathophysiological role of IFN-lambda and its possible use in clinical practice against endemic viruses, such as influenza virus as well as the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Twit Text FOAVip Type III interferons disrupt the lung epithelial barrier upon viral recognition ????Science http://www.kidney.de/pget.php?&tw=1&pmid=32527925 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32527925 #FOAvip English Wikipedia <ref>{{Cite pmid|32527925}}</ref> Type III interferons disrupt the lung epithelial barrier upon viral recognition #MMPMID32527925 Broggi A; Ghosh S; Sposito B; Spreafico R; Balzarini F; Lo Cascio A; Clementi N; De Santis M; Mancini N; Granucci F; Zanoni I Science 2020[Aug]; 369 (6504): 706-712 PMID32527925show ga Viral infections of the lower respiratory tract are a leading cause of mortality. Mounting evidence indicates that most severe cases are characterized by aberrant immune responses and do not depend on viral burden. In this study, we assessed how type III interferons (IFN-lambda) contribute to the pathogenesis induced by RNA viruses. We report that IFN-lambda is present in the lower, but not upper, airways of patients with coronavirus disease 2019 (COVID-19). In mice, we demonstrate that IFN-lambda produced by lung dendritic cells in response to a synthetic viral RNA induces barrier damage, causing susceptibility to lethal bacterial superinfections. These findings provide a strong rationale for rethinking the pathophysiological role of IFN-lambda and its possible use in clinical practice against endemic viruses, such as influenza virus as well as the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. |*Betacoronavirus[MESH] |Animals[MESH] |Bronchoalveolar Lavage Fluid/immunology[MESH] |COVID-19[MESH] |Cell Proliferation[MESH] |Coronavirus Infections/*immunology/*metabolism[MESH] |Cytokines/metabolism[MESH] |Dendritic Cells/*metabolism[MESH] |Humans[MESH] |Interferon Lambda[MESH] |Interferon Type I/metabolism[MESH] |Interferons/metabolism/*physiology[MESH] |Lung/immunology/*metabolism/*pathology[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Nasopharynx/immunology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/*metabolism[MESH] |Poly I-C/administration & dosage[MESH] |Respiratory Mucosa/pathology[MESH] |SARS-CoV-2[MESH] |Signal Transduction[MESH] |Staphylococcal Infections/metabolism[MESH] |Superinfection[MESH]Type III interferons disrupt the lung epithelial barrier upon viral re(epmc).pdf DeepDyve Pubget Overpricing