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10.1016/j.jaut.2020.102502

http://scihub22266oqcxt.onion/10.1016/j.jaut.2020.102502
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32527675!7832807!32527675
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suck abstract from ncbi


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pmid32527675      J+Autoimmun 2020 ; 112 (ä): 102502
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  • SARS-CoV-2 infection in patients with autoimmune rheumatic diseases in northeast Italy: A cross-sectional study on 916 patients #MMPMID32527675
  • Zen M; Fuzzi E; Astorri D; Saccon F; Padoan R; Ienna L; Cozzi G; Depascale R; Zanatta E; Gasparotto M; Benvenuti F; Bindoli S; Gatto M; Felicetti M; Ortolan A; Campaniello D; Larosa M; Lorenzin M; Ramonda R; Sfriso P; Schiavon F; Iaccarino L; Doria A
  • J Autoimmun 2020[Aug]; 112 (ä): 102502 PMID32527675show ga
  • BACKGROUND: Whether patients with autoimmune rheumatic diseases (ARD) have a higher risk for SARS-CoV-2 infection (COVID-19) and how SARS-CoV-2 pandemic impacts on adherence to therapy has not been fully elucidated. We assessed the rate and clinical presentation of COVID-19, and adherence to therapy in a large cohort of patients with ARD followed-up in a tertiary University-Hospital in Northeast Italy. METHODS: Between April 9th and April 25th(,) 2020, after SARS-CoV-2 infection peak, a telephone survey investigating the impact of COVID-19 on patients with systemic lupus erythematosus (SLE), systemic sclerosis (SSc), rheumatoid arthritis (RA), ANCA-associated vasculitis (AAV), and idiopathic inflammatory myopathies (IIM) was administered. Demographics, disease activity status, therapy, occupational exposure, and adherence to social distancing advise were also collected. RESULTS: 916 patients (397 SLE, 182 AAV, 176 SSc, 111 RA, 50 IIM) completed the survey. 148 patients developed at least one symptom compatible with COVID-19 (cough 96, sore throat 64, fever 64, arthromyalgias 59, diarrhea 26, conjunctivitis 18, ageusia/hyposmia, 18). Among the 916 patients, 65 (7.1%) underwent SARS-CoV-2 nasopharyngeal swab (18 symptomatic and 47 asymptomatic), 2 (0.21%) tested positive, a proportion similar to that observed in the general population of the Veneto region. No deaths occurred. 31 patients (3.4%) withdrew >/=1 medication, mainly immunosuppressants or biologics. Adoption of social distancing was observed by 860 patients (93.9%), including 335 (36.6%) who adopted it before official lockdown. CONCLUSIONS: COVID-19 incidence seems to be similar in our cohort compared to the general population. Adherence to therapy and to social distancing advise was high.
  • |*Betacoronavirus[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Autoimmune Diseases/diagnosis/*drug therapy/virology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/diagnosis/*drug therapy/pathology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunosuppressive Agents/*administration & dosage[MESH]
  • |Italy[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/diagnosis/*drug therapy/pathology[MESH]
  • |Rheumatic Diseases/diagnosis/*drug therapy/virology[MESH]


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