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10.3390/genes11060637

http://scihub22266oqcxt.onion/10.3390/genes11060637
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32526937!7349679!32526937
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suck abstract from ncbi


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pmid32526937      Genes+(Basel) 2020 ; 11 (6): ä
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  • Analysis of the Hosts and Transmission Paths of SARS-CoV-2 in the COVID-19 Outbreak #MMPMID32526937
  • Dong R; Pei S; Yin C; He RL; Yau SS
  • Genes (Basel) 2020[Jun]; 11 (6): ä PMID32526937show ga
  • The severe respiratory disease COVID-19 was initially reported in Wuhan, China, in December 2019, and spread into many provinces from Wuhan. The corresponding pathogen was soon identified as a novel coronavirus named SARS-CoV-2 (formerly, 2019-nCoV). As of 2 May, 2020, over 3 million COVID-19 cases had been confirmed, and 235,290 deaths had been reported globally, and the numbers are still increasing. It is important to understand the phylogenetic relationship between SARS-CoV-2 and known coronaviruses, and to identify its hosts for preventing the next round of emergency outbreak. In this study, we employ an effective alignment-free approach, the Natural Vector method, to analyze the phylogeny and classify the coronaviruses based on genomic and protein data. Our results show that SARS-CoV-2 is closely related to, but distinct from the SARS-CoV branch. By analyzing the genetic distances from the SARS-CoV-2 strain to the coronaviruses residing in animal hosts, we establish that the most possible transmission path originates from bats to pangolins to humans.
  • |*Models, Biological[MESH]
  • |Animals[MESH]
  • |Betacoronavirus/classification/*genetics[MESH]
  • |COVID-19[MESH]
  • |Chiroptera/virology[MESH]
  • |Coronavirus 3C Proteases[MESH]
  • |Coronavirus Infections/*transmission/virology[MESH]
  • |Coronavirus/classification/*genetics[MESH]
  • |Cysteine Endopeptidases/chemistry/genetics[MESH]
  • |Disease Outbreaks[MESH]
  • |Disease Reservoirs[MESH]
  • |Humans[MESH]
  • |Mammals/classification/virology[MESH]
  • |Pandemics[MESH]
  • |Phylogeny[MESH]
  • |Pneumonia, Viral/*transmission/virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Spike Glycoprotein, Coronavirus/chemistry/genetics[MESH]


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