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10.1016/j.mehy.2020.109802

http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.109802
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32526507!7239001!32526507
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suck abstract from ncbi


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pmid32526507      Med+Hypotheses 2020 ; 144 (ä): 109802
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  • Use of hydroxychloroquine and interferon alpha-2b for the prophylaxis of COVID-19 #MMPMID32526507
  • Yang A; Yang C; Yang B
  • Med Hypotheses 2020[Nov]; 144 (ä): 109802 PMID32526507show ga
  • The ongoing pandemic of COVID-19 infection demands efforts to reduce spread. In order to eradicate an infectious disease, a method of prevention with low social cost is the most effective way. While we wait for new therapies and a vaccine, we are proposing a solution based on the existing knowledge in biomedical sciences. Here we propose to use low doses of hydroxychloroquine (50-100 mg daily orally) and intranasal interferon alpha-2b (IFN alpha-2b) spray (0.5 x 10(6) IU twice daily) for the prophylaxis of COVID-19. Although there are ongoing clinical trials to test the efficacy of hydroxychloroquine for prophylaxis, there has not been any proposal to test the efficacy of IFN alpha-2b together with hydroxychloroquine to increase protection against COVID-19. Since the two act on two different mechanisms, we strongly believe that the two could have additive effects in prophylaxis against COVID-19. We recommend using a randomized control study to prove efficacy and safety.
  • |Antiviral Agents/therapeutic use[MESH]
  • |COVID-19/*prevention & control[MESH]
  • |Drug Administration Schedule[MESH]
  • |Drug Therapy, Combination[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/*therapeutic use[MESH]
  • |Interferon alpha-2/*therapeutic use[MESH]
  • |Models, Theoretical[MESH]
  • |Randomized Controlled Trials as Topic[MESH]
  • |Recombinant Proteins/therapeutic use[MESH]


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