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10.1016/j.meegid.2020.104417 http://scihub22266oqcxt.onion/10.1016/j.meegid.2020.104417 32526370!7833518!32526370     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32526370&cmd=llinks): Failed to open stream: HTTP request failed! 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What is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19?|pdf=|usr=}}{{32526370}} gab.com Text What is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19 JO: Infect Genet Evol http://www.kidney.de/pget.php?&tw=1&pmid=32526370 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19, a pandemic associated with substantial morbidity and mortality. Despite of this, no vaccine or approved drug is available to eradicate the virus. In this manuscript, we present an alternative study area that may contribute to development of diagnostic biomarkers and therapeutic targets for COVID-19. We analyzed sixty SARS-CoV-2 genomes to identify regions that could work as virus-encoded miRNA seed sponges and potentially bind to human miRNA seed sites and prevent interaction with their native targets thereby relieving native miRNA suppression. MicroRNAs (miRNAs) are evolutionally conserved single-stranded RNAs that regulate gene expression at the posttranscriptional level by disrupting translation. MiRNAs are key players in variety of biological processes that regulate differentiation, development and activation of immune cells in both innate and adaptive immunity. We find 34 miRNAs for positive-sense viral RNA and 45 miRNAs for negative-sense that can strongly bind to certain key SARS-CoV-2 genes. The disruption and dysfunction of miRNAs may perturb the immune response and stimulate the release of inflammatory cytokines altering the cellular response to viral infection. Previous studies demonstrate that miRNAs have the potential to be used as diagnostic and therapeutic biomarkers. Therefore, its discovery and validation are essential for improving the diagnosis of infection and clinical monitoring in COVID-19. Twit Text FOAVip What is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19 ????Infect Genet Evol http://www.kidney.de/pget.php?&tw=1&pmid=32526370 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32526370 #FOAvip English Wikipedia <ref>{{Cite pmid|32526370}}</ref> What is the potential function of microRNAs as biomarkers and therapeutic targets in COVID-19? #MMPMID32526370 Guterres A; de Azeredo Lima CH; Miranda RL; Gadelha MR Infect Genet Evol 2020[Nov]; 85 (ä): 104417 PMID32526370show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19, a pandemic associated with substantial morbidity and mortality. Despite of this, no vaccine or approved drug is available to eradicate the virus. In this manuscript, we present an alternative study area that may contribute to development of diagnostic biomarkers and therapeutic targets for COVID-19. We analyzed sixty SARS-CoV-2 genomes to identify regions that could work as virus-encoded miRNA seed sponges and potentially bind to human miRNA seed sites and prevent interaction with their native targets thereby relieving native miRNA suppression. MicroRNAs (miRNAs) are evolutionally conserved single-stranded RNAs that regulate gene expression at the posttranscriptional level by disrupting translation. MiRNAs are key players in variety of biological processes that regulate differentiation, development and activation of immune cells in both innate and adaptive immunity. We find 34 miRNAs for positive-sense viral RNA and 45 miRNAs for negative-sense that can strongly bind to certain key SARS-CoV-2 genes. The disruption and dysfunction of miRNAs may perturb the immune response and stimulate the release of inflammatory cytokines altering the cellular response to viral infection. Previous studies demonstrate that miRNAs have the potential to be used as diagnostic and therapeutic biomarkers. Therefore, its discovery and validation are essential for improving the diagnosis of infection and clinical monitoring in COVID-19. |*Genetic Markers/drug effects[MESH] |Antiviral Agents/pharmacology/therapeutic use[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*genetics[MESH] |Evolution, Molecular[MESH] |Gene Expression Regulation/drug effects[MESH] |Humans[MESH] |MicroRNAs/drug effects/*genetics/metabolism[MESH] |Molecular Targeted Therapy[MESH] |RNA, Viral/genetics/metabolism[MESH] |SARS-CoV-2/drug effects/*genetics/physiology[MESH]What is the potential function of microRNAs as biomarkers and therapeu(epmc).pdf DeepDyve Pubget Overpricing