Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.ymeth.2020.06.004 http://scihub22266oqcxt.onion/10.1016/j.ymeth.2020.06.004 32526282!7278654!32526282     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Methods 2021 ; 185 (ä): 28-38 Nephropedia Template TP {{tp|p=32526282|t=2021. Computational modelling of flavivirus dynamics: The ins and outs |pdf=|usr=}}{{32526282}} gab.com Text Computational modelling of flavivirus dynamics: The ins and outs JO: Methods http://www.kidney.de/pget.php?&tw=1&pmid=32526282 #FOAvip Enveloped viruses such as the flaviviruses represent a significant burden to human health around the world, with hundreds of millions of people each year affected by dengue alone. In an effort to improve our understanding of the molecular basis for the infective mechanisms of these viruses, extensive computational modelling approaches have been applied to elucidate their conformational dynamics. Multiscale protocols have been developed to simulate flavivirus envelopes in close accordance with biophysical data, in particular derived from cryo-electron microscopy, enabling high-resolution refinement of their structures and elucidation of the conformational changes associated with adaptation both to host environments and to immunological factors such as antibodies. Likewise, integrative modelling efforts combining data from biophysical experiments and from genome sequencing with chemical modification are providing unparalleled insights into the architecture of the previously unresolved nucleocapsid complex. Collectively, this work provides the basis for the future rational design of new antiviral therapeutics and vaccine development strategies targeting enveloped viruses. Twit Text FOAVip Computational modelling of flavivirus dynamics: The ins and outs ????Methods http://www.kidney.de/pget.php?&tw=1&pmid=32526282 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32526282 #FOAvip English Wikipedia <ref>{{Cite pmid|32526282}}</ref> Computational modelling of flavivirus dynamics: The ins and outs #MMPMID32526282 Huber RG; Marzinek JK; Boon PLS; Yue W; Bond PJ Methods 2021[Jan]; 185 (ä): 28-38 PMID32526282show ga Enveloped viruses such as the flaviviruses represent a significant burden to human health around the world, with hundreds of millions of people each year affected by dengue alone. In an effort to improve our understanding of the molecular basis for the infective mechanisms of these viruses, extensive computational modelling approaches have been applied to elucidate their conformational dynamics. Multiscale protocols have been developed to simulate flavivirus envelopes in close accordance with biophysical data, in particular derived from cryo-electron microscopy, enabling high-resolution refinement of their structures and elucidation of the conformational changes associated with adaptation both to host environments and to immunological factors such as antibodies. Likewise, integrative modelling efforts combining data from biophysical experiments and from genome sequencing with chemical modification are providing unparalleled insights into the architecture of the previously unresolved nucleocapsid complex. Collectively, this work provides the basis for the future rational design of new antiviral therapeutics and vaccine development strategies targeting enveloped viruses. |*Models, Molecular[MESH] |Computational Biology/*methods/trends[MESH] |Flavivirus/*chemistry/genetics/*metabolism[MESH] |Genomics/methods[MESH] |Humans[MESH] |Proteomics/methods[MESH]Computational modelling of flavivirus dynamics: The ins and outs (epmc).pdf DeepDyve Pubget Overpricing