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Multigroup, Adaptively Randomized Trials Are Advantageous for Comparing Coronavirus Disease 2019 (COVID-19) Interventions #MMPMID32525715
Magaret AS; Jacob ST; Halloran ME; Guthrie KA; Magaret CA; Johnston C; Simon NR; Wald A
Ann Intern Med 2020[Oct]; 173 (7): 576-577 PMID32525715show ga
In this commentary, the authors explain and call for a broader use of outcome-adaptive randomization when designing clinical trials to test multiple COVID-19 interventions. This design potentially reduces the number of deaths or other adverse outcomes incurred during a trial.