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10.1096/fj.202001115R http://scihub22266oqcxt.onion/10.1096/fj.202001115R 32525600!7300732!32525600     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FASEB+J 2020 ; 34 (7): 8787-8795 Nephropedia Template TP {{tp|p=32525600|t=2020. Genetic gateways to COVID-19 infection: Implications for risk, severity, and outcomes |pdf=|usr=}}{{32525600}} gab.com Text Genetic gateways to COVID-19 infection: Implications for risk, severity, and outcomes JO: FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=32525600 #FOAvip The dynamics, such as transmission, spatial epidemiology, and clinical course of Coronavirus Disease-2019 (COVID-19) have emerged as the most intriguing features and remain incompletely understood. The genetic landscape of an individual in particular, and a population in general seems to play a pivotal role in shaping the above COVID-19 dynamics. Considering the implications of host genes in the entry and replication of SARS-CoV-2 and in mounting the host immune response, it appears that multiple genes might be crucially involved in the above processes. Herein, we propose three potentially important genetic gateways to COVID-19 infection; these could explain at least in part the discrepancies of its spread, severity, and mortality. The variations within Angiotensin-converting enzyme 2 (ACE2) gene might constitute the first genetic gateway, influencing the spatial transmission dynamics of COVID-19. The Human Leukocyte Antigen locus, a master regulator of immunity against infection seems to be crucial in influencing susceptibility and severity of COVID-19 and can be the second genetic gateway. The genes regulating Toll-like receptor and complement pathways and subsequently cytokine storm induced exaggerated inflammatory pathways seem to underlie the severity of COVID-19, and such genes might represent the third genetic gateway. Host-pathogen interaction is a complex event and some additional genes might also contribute to the dynamics of COVID-19. Overall, these three genetic gateways proposed here might be the critical host determinants governing the risk, severity, and outcome of COVID-19. Genetic variations within these gateways could be key in influencing geographical discrepancies of COVID-19. Twit Text FOAVip Genetic gateways to COVID-19 infection: Implications for risk, severity, and outcomes ????FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=32525600 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32525600 #FOAvip English Wikipedia <ref>{{Cite pmid|32525600}}</ref> Genetic gateways to COVID-19 infection: Implications for risk, severity, and outcomes #MMPMID32525600 Debnath M; Banerjee M; Berk M FASEB J 2020[Jul]; 34 (7): 8787-8795 PMID32525600show ga The dynamics, such as transmission, spatial epidemiology, and clinical course of Coronavirus Disease-2019 (COVID-19) have emerged as the most intriguing features and remain incompletely understood. The genetic landscape of an individual in particular, and a population in general seems to play a pivotal role in shaping the above COVID-19 dynamics. Considering the implications of host genes in the entry and replication of SARS-CoV-2 and in mounting the host immune response, it appears that multiple genes might be crucially involved in the above processes. Herein, we propose three potentially important genetic gateways to COVID-19 infection; these could explain at least in part the discrepancies of its spread, severity, and mortality. The variations within Angiotensin-converting enzyme 2 (ACE2) gene might constitute the first genetic gateway, influencing the spatial transmission dynamics of COVID-19. The Human Leukocyte Antigen locus, a master regulator of immunity against infection seems to be crucial in influencing susceptibility and severity of COVID-19 and can be the second genetic gateway. The genes regulating Toll-like receptor and complement pathways and subsequently cytokine storm induced exaggerated inflammatory pathways seem to underlie the severity of COVID-19, and such genes might represent the third genetic gateway. Host-pathogen interaction is a complex event and some additional genes might also contribute to the dynamics of COVID-19. Overall, these three genetic gateways proposed here might be the critical host determinants governing the risk, severity, and outcome of COVID-19. Genetic variations within these gateways could be key in influencing geographical discrepancies of COVID-19. |*Pandemics[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus/*physiology[MESH] |COVID-19[MESH] |Complement Activation/*genetics[MESH] |Coronavirus Infections/complications/*genetics/immunology/transmission[MESH] |Cytokine Release Syndrome/etiology/genetics[MESH] |Disease Resistance/immunology[MESH] |Genetic Predisposition to Disease[MESH] |Genetic Variation[MESH] |HLA Antigens/*genetics/immunology[MESH] |Host-Pathogen Interactions/*genetics/immunology[MESH] |Humans[MESH] |Inflammation[MESH] |Metagenomics[MESH] |Mutation, Missense[MESH] |Peptidyl-Dipeptidase A/*genetics/physiology[MESH] |Pneumonia, Viral/complications/*genetics/immunology/transmission[MESH] |Prognosis[MESH] |Quantitative Trait Loci[MESH] |Racial Groups/genetics[MESH] |Receptors, Virus/*genetics/physiology[MESH] |Risk[MESH] |SARS-CoV-2[MESH] |Toll-Like Receptors/*genetics/immunology[MESH]Genetic gateways to COVID-19 infection: Implications for risk, severit(epmc).pdf DeepDyve Pubget Overpricing