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10.1016/j.ejphar.2020.173237 http://scihub22266oqcxt.onion/10.1016/j.ejphar.2020.173237 32525005!7276140!32525005     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Pharmacol 2020 ; 882 (ä): 173237 Nephropedia Template TP {{tp|p=32525005|t=2020. Effective block by pirfenidone, an antifibrotic pyridone compound (5-methyl-1-phenylpyridin-2 H-1 -one), on hyperpolarization-activated cation current: An additional but distinctive target |pdf=|usr=}}{{32525005}} gab.com Text Effective block by pirfenidone, an antifibrotic pyridone compound (5-methyl-1-phenylpyridin-2 H-1 -one), on hyperpolarization-activated cation current: An additional but distinctive target JO: Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32525005 #FOAvip Pirfenidone (PFD), a pyridone compound, is well recognized as an antifibrotic agent tailored for the treatment of idiopathic pulmonary fibrosis. Recently, through its anti-inflammatory and anti-oxidant effects, PFD based clinical trial has also been launched for the treatment of coronavirus disease (COVID-19). To what extent this drug can perturb membrane ion currents remains largely unknown. Herein, the exposure to PFD was observed to depress the amplitude of hyperpolarization-activated cation current (I(h)) in combination with a considerable slowing in the activation time of the current in pituitary GH(3) cells. In the continued presence of ivabradine or zatebradine, subsequent application of PFD decreased I(h) amplitude further. The presence of PFD resulted in a leftward shift in I(h) activation curve without changes in the gating charge. The addition of this compound also led to a reduction in area of voltage-dependent hysteresis evoked by long-lasting inverted triangular (downsloping and upsloping) ramp pulse. Neither the amplitude of M-type nor erg-mediated K(+) current was altered by its presence. In whole-cell potential recordings, addition of PFD reduced the firing frequency, and this effect was accompanied by the depression in the amplitude of sag voltage elicited by hyperpolarizing current stimulus. Overall, this study highlights evidence that PFD is capable of perturbing specific ionic currents, revealing a potential additional impact on functional activities of different excitable cells. Twit Text FOAVip Effective block by pirfenidone, an antifibrotic pyridone compound (5-methyl-1-phenylpyridin-2 H-1 -one), on hyperpolarization-activated cation current: An additional but distinctive target ????Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32525005 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32525005 #FOAvip English Wikipedia <ref>{{Cite pmid|32525005}}</ref> Effective block by pirfenidone, an antifibrotic pyridone compound (5-methyl-1-phenylpyridin-2 H-1 -one), on hyperpolarization-activated cation current: An additional but distinctive target #MMPMID32525005 Chang WT; Ragazzi E; Liu PY; Wu SN Eur J Pharmacol 2020[Sep]; 882 (ä): 173237 PMID32525005show ga Pirfenidone (PFD), a pyridone compound, is well recognized as an antifibrotic agent tailored for the treatment of idiopathic pulmonary fibrosis. Recently, through its anti-inflammatory and anti-oxidant effects, PFD based clinical trial has also been launched for the treatment of coronavirus disease (COVID-19). To what extent this drug can perturb membrane ion currents remains largely unknown. Herein, the exposure to PFD was observed to depress the amplitude of hyperpolarization-activated cation current (I(h)) in combination with a considerable slowing in the activation time of the current in pituitary GH(3) cells. In the continued presence of ivabradine or zatebradine, subsequent application of PFD decreased I(h) amplitude further. The presence of PFD resulted in a leftward shift in I(h) activation curve without changes in the gating charge. The addition of this compound also led to a reduction in area of voltage-dependent hysteresis evoked by long-lasting inverted triangular (downsloping and upsloping) ramp pulse. Neither the amplitude of M-type nor erg-mediated K(+) current was altered by its presence. In whole-cell potential recordings, addition of PFD reduced the firing frequency, and this effect was accompanied by the depression in the amplitude of sag voltage elicited by hyperpolarizing current stimulus. Overall, this study highlights evidence that PFD is capable of perturbing specific ionic currents, revealing a potential additional impact on functional activities of different excitable cells. |Animals[MESH] |Betacoronavirus/metabolism[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Cations/metabolism[MESH] |Cell Line, Tumor[MESH] |Cell Membrane/*drug effects/metabolism[MESH] |Coronavirus Infections/*drug therapy/virology[MESH] |Humans[MESH] |Ion Channels/drug effects/metabolism[MESH] |Ion Transport/drug effects[MESH] |Membrane Potentials/drug effects[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/virology[MESH] |Potassium/metabolism[MESH] |Pyridones/*pharmacology/therapeutic use[MESH] |Rats[MESH] |SARS-CoV-2[MESH]Effective block by pirfenidone, an antifibrotic pyridone compound (5-(epmc).pdf DeepDyve Pubget Overpricing