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10.1073/pnas.2008176117 http://scihub22266oqcxt.onion/10.1073/pnas.2008176117 32522874!7334499!32522874     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2020 ; 117 (26): 15193-15199 Nephropedia Template TP {{tp|p=32522874|t=2020. Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses |pdf=|usr=}}{{32522874}} gab.com Text Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=32522874 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses an immediate, major threat to public health across the globe. Here we report an in-depth molecular analysis to reconstruct the evolutionary origins of the enhanced pathogenicity of SARS-CoV-2 and other coronaviruses that are severe human pathogens. Using integrated comparative genomics and machine learning techniques, we identify key genomic features that differentiate SARS-CoV-2 and the viruses behind the two previous deadly coronavirus outbreaks, SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), from less pathogenic coronaviruses. These features include enhancement of the nuclear localization signals in the nucleocapsid protein and distinct inserts in the spike glycoprotein that appear to be associated with high case fatality rate of these coronaviruses as well as the host switch from animals to humans. The identified features could be crucial contributors to coronavirus pathogenicity and possible targets for diagnostics, prognostication, and interventions. Twit Text FOAVip Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=32522874 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32522874 #FOAvip English Wikipedia <ref>{{Cite pmid|32522874}}</ref> Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses #MMPMID32522874 Gussow AB; Auslander N; Faure G; Wolf YI; Zhang F; Koonin EV Proc Natl Acad Sci U S A 2020[Jun]; 117 (26): 15193-15199 PMID32522874show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses an immediate, major threat to public health across the globe. Here we report an in-depth molecular analysis to reconstruct the evolutionary origins of the enhanced pathogenicity of SARS-CoV-2 and other coronaviruses that are severe human pathogens. Using integrated comparative genomics and machine learning techniques, we identify key genomic features that differentiate SARS-CoV-2 and the viruses behind the two previous deadly coronavirus outbreaks, SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), from less pathogenic coronaviruses. These features include enhancement of the nuclear localization signals in the nucleocapsid protein and distinct inserts in the spike glycoprotein that appear to be associated with high case fatality rate of these coronaviruses as well as the host switch from animals to humans. The identified features could be crucial contributors to coronavirus pathogenicity and possible targets for diagnostics, prognostication, and interventions. |*Evolution, Molecular[MESH] |*Genome, Viral[MESH] |Animals[MESH] |Betacoronavirus/classification/*genetics/pathogenicity[MESH] |Host Specificity[MESH] |Humans[MESH] |Machine Learning[MESH] |Middle East Respiratory Syndrome Coronavirus/classification/genetics/pathogenicity[MESH] |Mutagenesis, Insertional[MESH] |Nuclear Localization Signals/genetics[MESH] |Nucleocapsid Proteins/chemistry/*genetics[MESH] |Phylogeny[MESH] |SARS-CoV-2[MESH] |Sequence Homology[MESH] |Spike Glycoprotein, Coronavirus/chemistry/*genetics[MESH]Genomic determinants of pathogenicity in SARS-CoV-2 and other human c(epmc).pdf DeepDyve Pubget Overpricing