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10.3390/ijms21114084 http://scihub22266oqcxt.onion/10.3390/ijms21114084 32521619!7312898!32521619     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2020 ; 21 (11): ä Nephropedia Template TP {{tp|p=32521619|t=2020. Redox-Modulating Agents in the Treatment of Viral Infections |pdf=|usr=}}{{32521619}} gab.com Text Redox-Modulating Agents in the Treatment of Viral Infections JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32521619 #FOAvip Viruses use cell machinery to replicate their genome and produce viral proteins. For this reason, several intracellular factors, including the redox state, might directly or indirectly affect the progression and outcome of viral infection. In physiological conditions, the redox balance between oxidant and antioxidant species is maintained by enzymatic and non-enzymatic systems, and it finely regulates several cell functions. Different viruses break this equilibrium and induce an oxidative stress that in turn facilitates specific steps of the virus lifecycle and activates an inflammatory response. In this context, many studies highlighted the importance of redox-sensitive pathways as novel cell-based targets for therapies aimed at blocking both viral replication and virus-induced inflammation. In the review, we discuss the most recent findings in this field. In particular, we describe the effects of natural or synthetic redox-modulating molecules in inhibiting DNA or RNA virus replication as well as inflammatory pathways. The importance of the antioxidant transcription factor Nrf2 is also discussed. Most of the data reported here are on influenza virus infection. We believe that this approach could be usefully applied to fight other acute respiratory viral infections characterized by a strong inflammatory response, like COVID-19. Twit Text FOAVip Redox-Modulating Agents in the Treatment of Viral Infections ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32521619 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32521619 #FOAvip English Wikipedia <ref>{{Cite pmid|32521619}}</ref> Redox-Modulating Agents in the Treatment of Viral Infections #MMPMID32521619 Checconi P; De Angelis M; Marcocci ME; Fraternale A; Magnani M; Palamara AT; Nencioni L Int J Mol Sci 2020[Jun]; 21 (11): ä PMID32521619show ga Viruses use cell machinery to replicate their genome and produce viral proteins. For this reason, several intracellular factors, including the redox state, might directly or indirectly affect the progression and outcome of viral infection. In physiological conditions, the redox balance between oxidant and antioxidant species is maintained by enzymatic and non-enzymatic systems, and it finely regulates several cell functions. Different viruses break this equilibrium and induce an oxidative stress that in turn facilitates specific steps of the virus lifecycle and activates an inflammatory response. In this context, many studies highlighted the importance of redox-sensitive pathways as novel cell-based targets for therapies aimed at blocking both viral replication and virus-induced inflammation. In the review, we discuss the most recent findings in this field. In particular, we describe the effects of natural or synthetic redox-modulating molecules in inhibiting DNA or RNA virus replication as well as inflammatory pathways. The importance of the antioxidant transcription factor Nrf2 is also discussed. Most of the data reported here are on influenza virus infection. We believe that this approach could be usefully applied to fight other acute respiratory viral infections characterized by a strong inflammatory response, like COVID-19. |Animals[MESH] |Antiviral Agents/*therapeutic use[MESH] |COVID-19 Drug Treatment[MESH] |Coronavirus Infections/drug therapy[MESH] |Glutathione/metabolism[MESH] |Humans[MESH] |Inflammation/drug therapy[MESH] |Influenza, Human/drug therapy[MESH] |Oxidation-Reduction/*drug effects[MESH] |Virus Diseases/*drug therapy/immunology/pathology[MESH]Redox-Modulating Agents in the Treatment of Viral Infections (epmc).pdf DeepDyve Pubget Overpricing