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10.1080/15548627.2020.1779531 http://scihub22266oqcxt.onion/10.1080/15548627.2020.1779531 32521191!7751564!32521191     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autophagy 2020 ; 16 (12): 2267-2270 Nephropedia Template TP {{tp|p=32521191|t=2020. Open questions for harnessing autophagy-modulating drugs in the SARS-CoV-2 war: hope or hype?|pdf=|usr=}}{{32521191}} gab.com Text Open questions for harnessing autophagy-modulating drugs in the SARS-CoV-2 war: hope or hype JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=32521191 #FOAvip At a time when the world faces an emotional breakdown, crushing our dreams, if not, taking our lives, we realize that together we must fight the war against the COVID-19 outbreak even if almost the majority of the scientific community finds itself confined at home. Every day, we, scientists, listen to the latest news with its promises and announcements. Across the world, a surge of clinical trials trying to cure or slow down the coronavirus pandemic has been launched to bring hope instead of fear and despair. One first proposed clinical trial has drawn worldwide hype to the benefit of chloroquine (CQ), in the treatment of patients infected by the recently emerged deadly coronavirus (SARS-CoV-2). We should consider this information in light of the long-standing anti-inflammatory and anti-viral properties of CQ-related drugs. Yet, none of the articles promoting the use of CQ in the current pandemic evoked a possible molecular or cellular mechanism of action that could account for any efficacy. Here, given the interaction of viruses with macroautophagy (hereafter referred to as autophagy), a CQ-sensitive anti-viral safeguard pathway, we would like to discuss the pros, but also the cons concerning the current therapeutic options targeting this process. Twit Text FOAVip Open questions for harnessing autophagy-modulating drugs in the SARS-CoV-2 war: hope or hype ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=32521191 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32521191 #FOAvip English Wikipedia <ref>{{Cite pmid|32521191}}</ref> Open questions for harnessing autophagy-modulating drugs in the SARS-CoV-2 war: hope or hype? #MMPMID32521191 Brest P; Benzaquen J; Klionsky DJ; Hofman P; Mograbi B Autophagy 2020[Dec]; 16 (12): 2267-2270 PMID32521191show ga At a time when the world faces an emotional breakdown, crushing our dreams, if not, taking our lives, we realize that together we must fight the war against the COVID-19 outbreak even if almost the majority of the scientific community finds itself confined at home. Every day, we, scientists, listen to the latest news with its promises and announcements. Across the world, a surge of clinical trials trying to cure or slow down the coronavirus pandemic has been launched to bring hope instead of fear and despair. One first proposed clinical trial has drawn worldwide hype to the benefit of chloroquine (CQ), in the treatment of patients infected by the recently emerged deadly coronavirus (SARS-CoV-2). We should consider this information in light of the long-standing anti-inflammatory and anti-viral properties of CQ-related drugs. Yet, none of the articles promoting the use of CQ in the current pandemic evoked a possible molecular or cellular mechanism of action that could account for any efficacy. Here, given the interaction of viruses with macroautophagy (hereafter referred to as autophagy), a CQ-sensitive anti-viral safeguard pathway, we would like to discuss the pros, but also the cons concerning the current therapeutic options targeting this process. |*COVID-19 Drug Treatment[MESH] |Anti-Inflammatory Agents/pharmacology/*therapeutic use[MESH] |Antiviral Agents/pharmacology/therapeutic use[MESH] |Autophagy/*drug effects/physiology[MESH] |COVID-19/epidemiology/immunology/pathology[MESH] |Chloroquine/analogs & derivatives/pharmacology/*therapeutic use[MESH] |Disease Eradication/methods[MESH] |Drug Repositioning/methods/trends[MESH] |Drug-Related Side Effects and Adverse Reactions/epidemiology[MESH] |Ebolavirus/drug effects[MESH] |HIV/drug effects[MESH] |History, 21st Century[MESH] |Humans[MESH] |Hydroxychloroquine/pharmacology/therapeutic use[MESH] |Malaria/drug therapy[MESH] |Pandemics[MESH] |Plasmodium malariae/drug effects[MESH] |SARS-CoV-2/*drug effects/immunology/pathogenicity[MESH]Open questions for harnessing autophagy-modulating drugs in the SARS-C(epmc).pdf DeepDyve Pubget Overpricing