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10.6061/clinics/2020/e1983

http://scihub22266oqcxt.onion/10.6061/clinics/2020/e1983
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32520225!7247749!32520225
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suck abstract from ncbi


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pmid32520225      Clinics+(Sao+Paulo) 2020 ; 75 (ä): e1983
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  • COVID-19 in solid organ transplantation patients: A systematic review #MMPMID32520225
  • Nacif LS; Zanini LY; Waisberg DR; Pinheiro RS; Galvao F; Andraus W; D'Albuquerque LC
  • Clinics (Sao Paulo) 2020[]; 75 (ä): e1983 PMID32520225show ga
  • Coronavirus disease (COVID-19) rapidly progresses to severe acute respiratory syndrome. This review aimed at collating available data on COVID-19 infection in solid organ transplantation (SOT) patients. We performed a systematic review of SOT patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The MEDLINE and PubMed databases were electronically searched and updated until April 20, 2020. The MeSH terms used were "COVID-19" AND "Transplant." Thirty-nine COVID-19 cases were reported among SOT patients. The median interval for developing SARS-CoV-2 infection was 4 years since transplantation, and the fatality rate was 25.64% (10/39). Sixteen cases were described in liver transplant (LT) patients, and the median interval since transplantation was 5 years. The fatality rate among LT patients was 37.5% (6/16), with death occurring more than 3 years after LT. The youngest patient who died was 59 years old; there were no deaths among children. Twenty-three cases were described in kidney transplant (KT) patients. The median interval since transplantation was 4 years, and the fatality rate was 17.4% (4/23). The youngest patient who died was 71 years old. Among all transplant patients, COVID-19 had the highest fatality rate in patients older than 60 years : LT, 62.5% vs 12.5% (p=0.006); KT 44.44% vs 0 (p=0.039); and SOT, 52.94% vs 4.54% (p=0.001). This study presents a novel description of COVID-19 in abdominal SOT recipients. Furthermore, we alert medical professionals to the higher fatality risk in patients older than 60 years. (PROSPERO, registration number=CRD42020181299).
  • |*Betacoronavirus[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19[MESH]
  • |Child[MESH]
  • |Coronavirus Infections/*mortality[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Kidney Transplantation/*adverse effects/mortality[MESH]
  • |Liver Transplantation/*adverse effects/mortality[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*mortality[MESH]


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