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10.1039/d0fo00530d http://scihub22266oqcxt.onion/10.1039/d0fo00530d 32520031!ä!32520031 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Food+Funct 2020 ; 11 (6): 5565-5572 Nephropedia Template TP {{tp|p=32520031|t=2020. In silico evaluation of marine fish proteins as nutritional supplements for COVID-19 patients |pdf=|usr=}}{{32520031}} gab.com Text In silico evaluation of marine fish proteins as nutritional supplements for COVID-19 patients JO: Food Funct http://www.kidney.de/pget.php?&tw=1&pmid=32520031 #FOAvip To date, no specific drug has been discovered for the treatment of COVID-19 and hence, people are in a state of anxiety. Thus, there is an urgent need to search for various possible strategies including nutritional supplementation. In this study, we have tried to provide a reference for protein supplementation. Specifically, 20 marine fish proteins were subjected to in silico hydrolysis by gastrointestinal enzymes, and a large number of active peptides were generated. Then, the binding abilities of these peptides to SARS-CoV-2 main protease and monoamine oxidase A were assessed. The results showed that NADH dehydrogenase could be a good protein source in generating potent binders to the two enzymes, followed by cytochrome b. In addition, some high-affinity oligopeptides (VIQY, ICIY, PISQF, VISAW, AIPAW, and PVSQF) were identified as dual binders to the two enzymes. In summary, the supplementation of some fish proteins can be helpful for COVID-19 patients; the identified oligopeptides can be used as the lead compounds to design potential inhibitors against COVID-19 and anxiety. Twit Text FOAVip In silico evaluation of marine fish proteins as nutritional supplements for COVID-19 patients ????Food Funct http://www.kidney.de/pget.php?&tw=1&pmid=32520031 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32520031 #FOAvip English Wikipedia <ref>{{Cite pmid|32520031}}</ref> In silico evaluation of marine fish proteins as nutritional supplements for COVID-19 patients #MMPMID32520031 Yao Y; Luo Z; Zhang X Food Funct 2020[Jun]; 11 (6): 5565-5572 PMID32520031show ga To date, no specific drug has been discovered for the treatment of COVID-19 and hence, people are in a state of anxiety. Thus, there is an urgent need to search for various possible strategies including nutritional supplementation. In this study, we have tried to provide a reference for protein supplementation. Specifically, 20 marine fish proteins were subjected to in silico hydrolysis by gastrointestinal enzymes, and a large number of active peptides were generated. Then, the binding abilities of these peptides to SARS-CoV-2 main protease and monoamine oxidase A were assessed. The results showed that NADH dehydrogenase could be a good protein source in generating potent binders to the two enzymes, followed by cytochrome b. In addition, some high-affinity oligopeptides (VIQY, ICIY, PISQF, VISAW, AIPAW, and PVSQF) were identified as dual binders to the two enzymes. In summary, the supplementation of some fish proteins can be helpful for COVID-19 patients; the identified oligopeptides can be used as the lead compounds to design potential inhibitors against COVID-19 and anxiety. |*Dietary Supplements[MESH] |Animals[MESH] |Antiviral Agents/chemistry/*metabolism/therapeutic use[MESH] |Aquatic Organisms[MESH] |Betacoronavirus/enzymology/*metabolism[MESH] |COVID-19[MESH] |Coronavirus Infections/drug therapy/*virology[MESH] |Decapodiformes/metabolism[MESH] |Fish Proteins/chemistry/*metabolism/therapeutic use[MESH] |Fishes/metabolism[MESH] |Models, Molecular[MESH] |Molecular Docking Simulation[MESH] |Monoamine Oxidase Inhibitors[MESH] |Monoamine Oxidase/*metabolism[MESH] |Pandemics[MESH] |Perciformes/metabolism[MESH] |Pneumonia, Viral/drug therapy/*virology[MESH] |Protein Binding[MESH] |Protein Conformation[MESH] |SARS-CoV-2[MESH] |Salmon/metabolism[MESH]In silico evaluation of marine fish proteins as nutritional supplement(epmc).pdf DeepDyve Pubget Overpricing