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10.1002/ppul.24869

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32519809!7300763!32519809
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suck abstract from ncbi


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pmid32519809      Pediatr+Pulmonol 2020 ; 55 (8): 2115-2127
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  • What we know so far about Coronavirus Disease 2019 in children: A meta-analysis of 551 laboratory-confirmed cases #MMPMID32519809
  • Zhang L; Peres TG; Silva MVF; Camargos P
  • Pediatr Pulmonol 2020[Aug]; 55 (8): 2115-2127 PMID32519809show ga
  • AIM: To summarize what we know so far about coronavirus disease (COVID-19) in children. METHOD: We searched PubMed, Scientific Electronic Library Online, and Latin American and Caribbean Center on Health Sciences Information from 1 January 2020 to 4 May 2020. We selected randomized trials, observational studies, case series or case reports, and research letters of children ages birth to 18 years with laboratory-confirmed COVID-19. We conducted random-effects meta-analyses to calculate the weighted mean prevalence and 95% confidence interval (CI) or the weighted average means and 95% CI. RESULT: Forty-six articles reporting 551 cases of COVID-19 in children (aged 1 day-17.5 years) were included. Eighty-seven percent (95% CI: 77%-95%) of patients had household exposure to COVID-19. The most common symptoms and signs were fever (53%, 95% CI: 45%-61%), cough (39%, 95% CI: 30%-47%), and sore throat/pharyngeal erythema (14%, 95% CI: 4%-28%); however, 18% (95% CI: 11%-27%) of cases were asymptomatic. The most common radiographic and computed tomography (CT) findings were patchy consolidations (33%, 95% CI: 23%-43%) and ground glass opacities (28%, 95% CI: 18%-39%), but 36% (95% CI: 28%-45%) of patients had normal CT images. Antiviral agents were given to 74% of patients (95% CI: 52%-92%). Six patients, all with major underlying medical conditions, needed invasive mechanical ventilation, and one of them died. CONCLUSION: Previously healthy children with COVID-19 have mild symptoms. The diagnosis is generally suspected from history of household exposure to COVID-19 case. Children with COVID-19 and major underlying condition are more likely to have severe/critical disease and poor prognosis, even death.
  • |*Betacoronavirus[MESH]
  • |Adolescent[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Asymptomatic Infections[MESH]
  • |COVID-19[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Comorbidity[MESH]
  • |Coronavirus Infections/*diagnosis/diagnostic imaging/*epidemiology/mortality[MESH]
  • |Cough/etiology[MESH]
  • |Erythema/etiology[MESH]
  • |Female[MESH]
  • |Fever/etiology[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Infant, Newborn[MESH]
  • |Observational Studies as Topic[MESH]
  • |Pandemics[MESH]
  • |Pharyngitis[MESH]
  • |Pneumonia, Viral/*diagnosis/diagnostic imaging/*epidemiology/mortality[MESH]
  • |Randomized Controlled Trials as Topic[MESH]
  • |Respiration, Artificial/adverse effects[MESH]
  • |SARS-CoV-2[MESH]


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