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10.1016/j.jacc.2020.06.007

http://scihub22266oqcxt.onion/10.1016/j.jacc.2020.06.007
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32517963!7279721!32517963
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  • Prevalence and Impact of Myocardial Injury in Patients Hospitalized With COVID-19 Infection #MMPMID32517963
  • Lala A; Johnson KW; Januzzi JL; Russak AJ; Paranjpe I; Richter F; Zhao S; Somani S; Van Vleck T; Vaid A; Chaudhry F; De Freitas JK; Fayad ZA; Pinney SP; Levin M; Charney A; Bagiella E; Narula J; Glicksberg BS; Nadkarni G; Mancini DM; Fuster V
  • J Am Coll Cardiol 2020[Aug]; 76 (5): 533-546 PMID32517963show ga
  • BACKGROUND: The degree of myocardial injury, as reflected by troponin elevation, and associated outcomes among U.S. hospitalized patients with coronavirus disease-2019 (COVID-19) are unknown. OBJECTIVES: The purpose of this study was to describe the degree of myocardial injury and associated outcomes in a large hospitalized cohort with laboratory-confirmed COVID-19. METHODS: Patients with COVID-19 admitted to 1 of 5 Mount Sinai Health System hospitals in New York City between February 27, 2020, and April 12, 2020, with troponin-I (normal value <0.03 ng/ml) measured within 24 h of admission were included (n = 2,736). Demographics, medical histories, admission laboratory results, and outcomes were captured from the hospitals' electronic health records. RESULTS: The median age was 66.4 years, with 59.6% men. Cardiovascular disease (CVD), including coronary artery disease, atrial fibrillation, and heart failure, was more prevalent in patients with higher troponin concentrations, as were hypertension and diabetes. A total of 506 (18.5%) patients died during hospitalization. In all, 985 (36%) patients had elevated troponin concentrations. After adjusting for disease severity and relevant clinical factors, even small amounts of myocardial injury (e.g., troponin I >0.03 to 0.09 ng/ml; n = 455; 16.6%) were significantly associated with death (adjusted hazard ratio: 1.75; 95% CI: 1.37 to 2.24; p < 0.001) while greater amounts (e.g., troponin I >0.09 ng/dl; n = 530; 19.4%) were significantly associated with higher risk (adjusted HR: 3.03; 95% CI: 2.42 to 3.80; p < 0.001). CONCLUSIONS: Myocardial injury is prevalent among patients hospitalized with COVID-19; however, troponin concentrations were generally present at low levels. Patients with CVD are more likely to have myocardial injury than patients without CVD. Troponin elevation among patients hospitalized with COVID-19 is associated with higher risk of mortality.
  • |*Comorbidity[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Cardiovascular Diseases/*complications/epidemiology[MESH]
  • |Coronavirus Infections/*complications/epidemiology[MESH]
  • |Electronic Health Records[MESH]
  • |Female[MESH]
  • |Heart Injuries/complications/epidemiology[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Incidence[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Myocardial Infarction/*complications/epidemiology[MESH]
  • |Myocardium/*pathology[MESH]
  • |New York City[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/epidemiology[MESH]
  • |Prevalence[MESH]
  • |Risk Factors[MESH]
  • |Treatment Outcome[MESH]
  • |Troponin I/*blood[MESH]
  • |Young Adult[MESH]


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  • suck abstract from ncbi

    533 5.76 2020